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논문 기본 정보

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학술저널
저자정보
Jeong, Ho-Gul (Department of Oral and Maxillofacial Radiology, Yonsei University, College of Dentistry) Hwang, Jae Joon (Department of Oral and Maxillofacial Radiology, Yonsei University, College of Dentistry) Lee, Jeong-Hee (Department of Oral and Maxillofacial Radiology, Yonsei University, College of Dentistry) Kim, Young Hyun (Department of Oral and Maxillofacial Radiology, Yonsei University, College of Dentistry) Na, Ji Yeon (Department of Oral and Maxillofacial Radiology, Yonsei University, College of Dentistry) Han, Sang-Sun (Department of Oral and Maxillofacial Radiology, Yonsei University, College of Dentistry)
저널정보
대한영상치의학회 Imaging science in dentistry Imaging science in dentistry 제47권 제1호
발행연도
2017.1
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45 - 50 (6page)

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Purpose: The aim of this study was to investigate the incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after tooth extraction in patients with osteoporosis on oral bisphosphonates in Korea and to evaluate local factors affecting the development of BRONJ. Materials and Methods: The clinical records of 320 patients who underwent dental extraction while receiving oral bisphosphonates were reviewed. All patients had a healing period of more than 6 months following the extractions. Each patient's clinical record was used to assess the incidence of BRONJ; if BRONJ occurred, a further radiographic investigation was carried out to obtain a more definitive diagnosis. Various local factors including age, gender, extraction site, drug type, duration of administration, and C-terminal telopeptide (CTx) level were retrieved from the patients' clinical records for evaluating their effect on the incidence of BRONJ. Results: Among the 320 osteoporotic patients who underwent tooth extraction, 11 developed BRONJ, reflecting an incidence rate of 3.44%. Out of the local factors that may affect the incidence of BRONJ, gender, drug type, and CTx level showed no statistically significant effects, while statistically significant associations were found for age, extraction site, and duration of administration. The incidence of BRONJ increased with age, was greater in the mandible than the maxilla, and was associated with a duration of administration of more than 3 years. Conclusion: Tooth extraction in patients on oral bisphosphonates requires careful consideration of their age, the extraction site, and the duration of administration, and close postoperative follow-up should be carried out to facilitate effective early management.
#Bisphosphonate-Associated Osteonecrosis of the Jaw #Osteoporosis #Tooth Extraction #Risk Factors

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참고문헌 (21)

참고문헌 신청
Pazianas M / 2007 / A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates:prevalence, risk factors, and clinical characteristics / Clin Ther 29:1548~1558 google schola Tosteson AN / 2001 / Impact of hip and vertebral fractures on quality-adjusted life years / Osteoporos Int 12:1042~1049 google schola Saia G / 2010 / Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction / J Oral Maxillofac Surg 68:797~804 google schola Cummings SR / 1998 / Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention TriaI / JAMA 280:2077~2082 google schola Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group / Lancet 348:1535~1541 google schola

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