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논문 기본 정보

자료유형
학술저널
저자정보
Hong-Joon Kim (Department of Oral and Maxillofacial Surgery College of Medicine Uni) Tae-Jun Park (Department of Oral and Maxillofacial Sur) Kang-Min Ahn (Department of Oral and Maxillofacial Sur)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제38권 제2호
발행연도
2016.2
수록면
1 - 8 (8page)
DOI
10.1186/s40902-016-0052-6

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Background: Intravenous bisphosphonates have been used in metastatic breast cancer patients to reducepathologic bone fracture and bone pain. However, necrosis of the jaw has been reported in those who receivedintravenous bisphosphonates. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is caused by dentalextraction, dental implant surgery, and denture wearing; however, it occurs spontaneously. The purpose of thisstudy was to report BRONJ in metastatic breast cancer patients. Methods: Consecutive 25 female patients were referred from the Department of Oncology from 2008 to 2014for jaw bone discomfort. Staging of breast cancer, history of bisphosphonate infusion, etiology of BRONJ, andtreatment results were reviewed. Average age of the patients was 55.4 years old (38?74). Twelve maxillae and 16mandibles were involved. Conservative treatments such as irrigation, antibiotic medication, analgesics, and oralgargle were applied for all patients for the initial treatment. Patients who had sequestrum underwent debridementand primary closure. Results: The etiologies of BRONJ were dental extraction (19 cases), dental implant (2 cases), and endodontictreatment (1 case). However, three patients did not have any risk factors to cause BRONJ. Three patients died ofprogression of metastasis during follow-up periods. Surgical debridement was performed in 21 patients withsuccess in 18 patients. Three patients showed recurred bone exposure and infection after operation. Conclusions: Prevention of the BRONJ is critical in metastatic breast cancer patients. Conservative treatment toreduce pain, discomfort, and infection is recommended for the initial therapy. However, if there is a sequestrum,surgical debridement and primary closure is the key to treat the BRONJ.
#Conclusions: Prevention of the BRONJ is critical in metastatic breast cancer patients. Conservative treatment to reduce pain #discomfort #and infection is recommended for the initial therapy. However #if there is a sequestrum #surgical debridement and primary closure is the key to treat the BRONJ.

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참고문헌 (37)

참고문헌 신청
Ito H / 2016 / Molecular epidemiology, and possible real-world applications in breast cancer / Breast Cancer 23:33~38 google schola Bundred N / 2012 / Antiresorptive therapies in oncology and their effects on cancer progression / Cancer Treat Rev 38:776~786 google schola Piccioli A / 2015 / Bisphosphonate-related osteonecrosis of the jaw in patients with breast cancer / Eur J Orthop Surg Traumatol 25:29~37 google schola Gnant M / 2012 / Bisphosphonates: prevention of bone metastases in breast cancer / Recent Results Cancer Res 192:65~91 google schola Ahn KM / 2014 / Chapter 8. Bisphosphonate related osteonecrosis of the jaw in multiple myeloma. Multiple myeloma: risk factors, diagnosis and treatments / Nova Science publishers, Inc google schola

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