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논문 기본 정보

자료유형
학술저널
저자정보
Caitlin Fern Wee (National University of Singapore) Yao Hao Teo (National University of Singapore) Yao Neng Teo (National University of Singapore) Nicholas LX Syn (National University of Singapore) Ray Meng See (National University of Singapore) Shariel Leong (National University of Singapore) Alicia Swee Yan Yip (National University of Singapore) Zhi Xian Ong (National University of Singapore) Chi-Hang Lee (National University of Singapore) Mark Yan-Yee Chan (National University of Singapore) Kian-Keong Poh (National University of Singapore) Ching Ching Ong (National University Hospital) Lynette LS Teo (National University Hospital) Devinder Singh (National University Heart Centre Singapore) Benjamin YQ Tan (National University of Singapore) Leonard LL Yeo (National University of Singapore) William KF Kong (National University of Singapore) Tiong-Cheng Yeo (National University of Singapore) Raymond CC Wong (National University of Singapore) Ping Chai (National University of Singapore) Ching-Hui Sia (National University of Singapore)
저널정보
한국심초음파학회 Journal of Cardiovascular Imaging Journal of Cardiovascular Imaging 제30권 제3호
발행연도
2022.7
수록면
153 - 168 (16page)

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Recent studies have shown that sodium/glucose cotransporter 2 (SGLT2) inhibitors might exert favourable changes on cardiac parameters as observed on cardiovascular imaging. We conducted a systematic review and meta-analysis to determine the effects of SGLT2 inhibitors on cardiac imaging parameters. Four electronic databases (PubMed, Embase, Cochrane, Scopus) were searched for studies in which the effects of SGLT2 inhibitors on cardiac imaging parameters were examined. Studies in which a population was administered SGLT2 inhibitors and analysed by echocardiography and/or cardiac magnetic resonance (CMR) imaging were included. Random-effects pair-wise meta-analysis models were utilized to summarize the studies. A total of 11 randomized controlled trials was included with a combined cohort of 910 patients. Comparing patients receiving SGLT2 inhibitors with subjects receiving placebo, the mean change in CMR-measured left ventricular mass (LVM) was ?3.87 g (95% confidence interval [CI], ?7.77 to 0.04), that in left ventricular end-systolic volume (LVESV) was ?5.96 mL (95% CI, ?10.52 to ?1.41) for combined LVESV outcomes, that in left atrial volume index (LAVi) was ?1.78 mL/m2 (95% CI, ?3.01 to ?0.55) for combined LAVi outcomes, and that in echocardiography-measured E/e′ was ?0.73 (95% CI, ?1.43 to ?0.03). Between-group differences were not observed in LVM and LVESV after indexation. The only between-group difference that persisted was for LAVi. Treatment with SGLT2 inhibitors resulted in reduction in LAVi and E/e′ on imaging, indicating they might have an effect on outcomes associated with LV diastolic function.

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