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논문 기본 정보

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학술저널
저자정보
Ashcherkin Nikita (Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA) Abdalla Abdelmohaymin A. (Department of Pulmonary and Critical Care, Mayo Clinic, Scottsdale, AZ, USA) Gupta Simran (Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA) Bhatt Shubhang (Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA) Yee Claire I. (Department of Quantitative Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA) Cartin-Ceba Rodrigo (Department of Pulmonary and Critical Care, Mayo Clinic, Scottsdale, AZ, USA)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care Vol.39 No.2
발행연도
2024.5
수록면
251 - 256 (6page)
DOI
10.4266/acc.2023.01046

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Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce organ dysfunction in renal and cardiovascular disease. There are limited data on the role of SGLT2i in acute organ dysfunction. We conducted a study to assess the effect of SGLT2i taken prior to intensive care unit (ICU) admission in diabetic patients admitted with septic shock.Methods: This retrospective cohort study used electronic medical records and included diabetic patients admitted to the ICU with septic shock. We compared diabetic patients on SGLT2i to those who were not on SGLT2i prior to admission. The primary outcome was in-hospital mortality, and secondary outcomes included hospital and ICU length of stay, use of renal replacement therapy, and 28- and 90-day mortality. Results: A total of 98 diabetic patients was included in the study, 36 in the SGLT2i group and 62 in the non-SGLT2i group. The Sequential Organ Failure Assessment and Acute Physiology and Chronic Health Evaluation III scores were similar in the groups. Inpatient mortality was significantly lower in the SGLT2i group (5.6% vs. 27.4%, P=0.008). There was no significant difference in secondary outcomes.Conclusion: Our study found that diabetic patients on SGLT2i prior to hospitalization who were admitted to the ICU with septic shock had lower inpatient mortality compared to patients not on SGLT2i.

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