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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 864 - 870 (7page)
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초록· 키워드
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The uncoupling protein 4 (ucp-4) gene is involved in age-dependent neurodegeneration in C. elegans. Therefore, we aimed to investigate the mechanism underlying the association between mitochondrial uncoupling and neurodegeneration by examining the effects of uncoupling agents and ucp-4 overexpression in C. elegans. Treatment with either DNP or CCCP improved neuronal defects in wild type during aging. Uncoupling agents also restored neuronal phenotypes of ucp-4 mutants to those exhibited by wild type, while ucp-4 overexpression attenuated the severity of age-dependent neuro-degeneration. Neuronal improvements were further associated with reductions in mitochondrial membrane potentials. However, these age-dependent neuroprotective effects were limited in mitophagy-deficient mutant, pink-1, background. These results suggest that membrane uncoupling can attenuate age-dependent neurodegeneration by stimulating mitophagy.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Allen, G. F. / 2013 / Loss of iron triggers PINK1/Parkin-independent mitophagy / EMBO Rep 14:1127~1135
Ashrafi, G. / 2013 / The pathways of mitophagy for quality control and clearance of mitochondria / Cell Death Differ 20:31~42
Berezhnov, A. V. / 2016 / Intracellular pH modulates autophagy and mitophagy / J. Biol. Chem 291:8701~8708
Bossy-Wetzel, E. / 2008 / Mutant huntingtin and mitochondrial dysfunction / Trends Neurosci 31:609~616
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
Ashrafi, G. / 2013 / The pathways of mitophagy for quality control and clearance of mitochondria / Cell Death Differ 20:31~42
Berezhnov, A. V. / 2016 / Intracellular pH modulates autophagy and mitophagy / J. Biol. Chem 291:8701~8708
Bossy-Wetzel, E. / 2008 / Mutant huntingtin and mitochondrial dysfunction / Trends Neurosci 31:609~616
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
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