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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 688 - 695 (8page)
- DOI
- 10.14348/molcells.2021.0076
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초록· 키워드
오류제보하기
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a global health concern. Various SARS-CoV-2 vaccines have been developed and are being used for vaccination worldwide. However, no therapeutic agents against coronavirus disease 2019 (COVID-19) have been developed so far; therefore, new therapeutic agents are urgently needed. In the present study, we evaluated several hepatitis C virus direct-acting antivirals as potential candidates for drug repurposing against COVID-19. Theses include asunaprevir (a protease inhibitor), daclatasvir (an NS5A inhibitor), and sofosbuvir (an RNA polymerase inhibitor). We found that asunaprevir, but not sofosbuvir and daclatasvir, markedly inhibited SARS-CoV-2-induced cytopathic effects in Vero E6 cells. Both RNA and protein levels of SARS-CoV-2 were significantly decreased by treatment with asunaprevir. Moreover, asunaprevir profoundly decreased virion release from SARS-CoV-2-infected cells. A pseudoparticle entry assay revealed that asunaprevir blocked SARS-CoV-2 infection at the binding step of the viral life cycle. Furthermore, asunaprevir inhibited SARS-CoV-2 propagation in human lung Calu-3 cells. Collectively, we found that asunaprevir displays broad-spectrum antiviral activity and therefore might be worth developing as a new drug repurposing candidate for COVID-19.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Agostini, M. L. / 2018 / Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease / mBio 9:e00221~e00238
최재웅 / 2020 / Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation / Molecules and Cells 43(5):469~478
Chu, D. K. W. / 2020 / Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia / Clin. Chem 66:549~555
Ciotti, M. / 2019 / COVID-19 outbreak : an overview / Chemotherapy 64:215~223
Coleman, C.M. / 2014 / Coronaviruses: important emerging human pathogens / J. Virol 88:5209~5212
최재웅 / 2020 / Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation / Molecules and Cells 43(5):469~478
Chu, D. K. W. / 2020 / Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia / Clin. Chem 66:549~555
Ciotti, M. / 2019 / COVID-19 outbreak : an overview / Chemotherapy 64:215~223
Coleman, C.M. / 2014 / Coronaviruses: important emerging human pathogens / J. Virol 88:5209~5212
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