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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,351 - 1,359 (9page)
- DOI
- 10.1007/s13258-021-01136-6
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초록· 키워드
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Background COVID-19, as a novel coronavirus disease caused by new coronavirus SARS-CoV-2, spreads all over the world, and brings harm to human in many countries. Humans sufered a lot from both SARS-CoV-2 now and by SARS-CoV in the year 2003. It is important to understand the diferences and the relationships between these two types of viruses.
Objective To compare relative synonymous codon usage of ORF1ab gene in SARS-CoV-2 and SARS-CoV, relative synonymous codon usage of their genomes are studied in this paper from the bioinformatics perspective.
Methods The ORF1ab gene, which is an important non-structural polyprotein coding gene and now used for nucleic acid detection markers in many measurement method, in both SARS-CoV-2 (30 strains) and SARS-CoV (20 strains) are considered to be the research object in the present paper. The relative synonymous codon usage values of the ORF1ab gene are calculated to characterize the diferences and the evolutionary characteristics among 50 strains.
Results There is a signifcant diference between SARS-CoV and SARS-CoV-2 when the relative synonymous codon usage value of ORF1ab genes is concerned. The results suggest that codon usage pattern of SARS-CoV is more similar to human than that of the SARS-CoV-2, and that the inner diference in SARS-CoV-2 strains is larger than that of SARS-CoV, which denote the larger diversity exits in the SARS-CoV-2 virus.
Conclusion These results show that the relative synonymous codon usage values in the coronavirus could be used for further research on their evolutionary phenomenon.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Asadi-Pooya AA / 2019 / Central nervous system manifestations of COVID-19 : a systematic review. J Neurol Sci. https : //doi. org/10. 1016/j / jns 2020:116832
Bartolini B / 2020 / SARS-CoV-2phylogenetic analysis, Lazio Region, Italy, February–March 2020 / Emerg Infect Dis 26(8):1842~1845
Chen N / 2020 / Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China : a descriptive study / Lancet 395:507~513
Devaux CA / 2020 / ACE2 receptor polymorphism : Susceptibility to SARS-CoV-2, hypertension, multiorgan failure, and COVID-19 disease outcome / J Microbiol Immunol Infect 53(3):425~435
Dilucca M / 2020 / Codon usage and phenotypic divergences of SARS-CoV-2 genes / Viruses 12(5):498
Bartolini B / 2020 / SARS-CoV-2phylogenetic analysis, Lazio Region, Italy, February–March 2020 / Emerg Infect Dis 26(8):1842~1845
Chen N / 2020 / Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China : a descriptive study / Lancet 395:507~513
Devaux CA / 2020 / ACE2 receptor polymorphism : Susceptibility to SARS-CoV-2, hypertension, multiorgan failure, and COVID-19 disease outcome / J Microbiol Immunol Infect 53(3):425~435
Dilucca M / 2020 / Codon usage and phenotypic divergences of SARS-CoV-2 genes / Viruses 12(5):498
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