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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제7호
- 발행연도
- 2017.7
- 수록면
- 1,359 - 1,366 (8page)
- DOI
- 10.4014/jmb.1703.03060
이용수
초록· 키워드
오류제보하기
(E)-2-Methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol (MMPP), derived from butenal, is a recently synthesized Maillard reaction product. Owing to its novelty, little is known about the function of MMPP. In this study, we elucidated the effects of MMPP on apoptosis in cervical cancer by using the HeLa cervical cancer cell line, which is widely used in cancer research. We observed that MMPP was cytotoxic to HeLa cells and induced activation of caspase-3, -8, and -9, without affecting the expression of the viral oncogenes E6 and E7. In particular, the expression of the death receptors DR5 and FAS was significantly increased by MMPP treatment. There were no significant alterations of mitochondrial intrinsic factors.
Taking all these results together, our findings show that MMPP primarily induces apoptosis in HeLa cervical cancer cells via the extrinsic apoptotic signaling pathway, accompanied by an enhanced expression of death receptors.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int. J. Cancer 136:E359~E386
Wardak S. / 2016 / Human papillomavirus (HPV) and cervical cancer / Med. Dosw. Mikrobiol 68:73~84
Eun-Kyoung Yim / 2005 / The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis / Cancer Research and Treatment 37(6):319~324
Kwon T / 2016 / A1E reduces stemness and self-renewal in HPV 16-positive cervical cancer stem cells / BMC Complement. Altern. Med 16:42
Elmore S. / 2007 / Apoptosis: a review of programmed cell death / Toxicol. Pathol 35:495~516
Wardak S. / 2016 / Human papillomavirus (HPV) and cervical cancer / Med. Dosw. Mikrobiol 68:73~84
Eun-Kyoung Yim / 2005 / The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis / Cancer Research and Treatment 37(6):319~324
Kwon T / 2016 / A1E reduces stemness and self-renewal in HPV 16-positive cervical cancer stem cells / BMC Complement. Altern. Med 16:42
Elmore S. / 2007 / Apoptosis: a review of programmed cell death / Toxicol. Pathol 35:495~516
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