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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 123 - 130 (8page)
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Cancer is an unfavorable human disease, and the treatment commonly have side effects and can be ineffective. Since exploration and development of cancer treatment drugs is particularly demanding, this study aimed to investigate the anticancer activities of Polysiponia morrowii extracts (PME) on CT-26 and HeLa cells. The results showed that PME inhibited cell proliferation in a dose-dependent manner, with IC50 values of 41.04% in CT-26 and 48.51% in HeLa cell cultures. Moreover, cytological observation using Hoechst 33342 staining assay showed typical apoptotic morphology in both cancer cells, and production of sub-G1 DNA was induced by PME treatment in a dose-dependent manner, with 34.41% in CT-26 and 46.01% in HeLa cell cultures. These findings suggest that PME may have potential preventive effects or medicinal value in the treatment of colorectal and cervical cancers.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (42)
참고문헌 신청
Bray, F. / 2018 / Global cancer statistics 2018:GLOBOCAN estimates of incidence and mort ality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68(6):394~424
정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316
정규원 / 2019 / Prediction of Cancer Incidence and Mortality in Korea, 2019 / Cancer Research and Treatment 51(2):431~437
Arbyn, M. / 2018 / Estimates of incidence and mortality of cervical cancer in 2018: a world wide analysis / The Lancet Global Health 8(2):e191~e203
Monk, B. J. / 2009 / Phase III trial of four cispla tin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcino ma: a Gynecologic Oncology Group study / J Clin Oncol 27(28):4649~4655
정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316
정규원 / 2019 / Prediction of Cancer Incidence and Mortality in Korea, 2019 / Cancer Research and Treatment 51(2):431~437
Arbyn, M. / 2018 / Estimates of incidence and mortality of cervical cancer in 2018: a world wide analysis / The Lancet Global Health 8(2):e191~e203
Monk, B. J. / 2009 / Phase III trial of four cispla tin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcino ma: a Gynecologic Oncology Group study / J Clin Oncol 27(28):4649~4655
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