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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제3호
- 발행연도
- 2017.5
- 수록면
- 327 - 334 (8page)
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Epidemiologic interest in particulate matter (PM) is growing particularly because of its impact of respiratory health. It has been elucidated that PM evoked inflammatory signal in pulmonary epithelia. However, it has not been established Ca2+ signaling mechanisms involved in acute PM-derived signaling in pulmonary fibroblasts. In the present study, we explored dust particles PM modulated intracellular Ca2+ signaling and sought to provide a therapeutic strategy by antagonizing PM-induced intracellular Ca2+ signaling in human lung fibroblasts MRC5 cells. We demonstrated that PM10, less than 10 μm, induced intracellular Ca2+ signaling, which was mediated by extracellular Ca2+. The PM10-mediated intracellular Ca2+ signaling was attenuated by antioxidants, phospholipase blockers, polyADPR polymerase 1 inhibitor, and transient receptor potential melastatin 2 (TRPM2) inhibitors. In addition, PM-mediated increases in reactive oxygen species were attenuated by TRPM2 blockers, clotrimazole (CLZ) and N-(p-amylcinnamoyl) anthranilic acid (ACA). Our results showed that PM10 enhanced reactive oxygen species signal by measuring DCF fluorescence and the DCF signal attenuated by both TRPM2 blockers CLZ and ACA. Here, we suggest functional inhibition of TRPM2 channels as a potential therapeutic strategy for modulation of dust particlemediated signaling and oxidative stress accompanying lung diseases.
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참고문헌 (48)
참고문헌 신청
Kanatani KT / 2010 / Desert dust exposure is associated with increased risk of asthma hospitalization in children / Am J Respir Crit Care Med 182:1475~1481
He M / 2012 / Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumoniae / Toxicol Appl Pharmacol 258:237~247
Yeo NK / 2010 / Asian sand dust enhances rhinovirus-induced cytokine secretion and viral replication in human nasal epithelial cells / Inhal Toxicol 22:1038~1045
Wilker EH / 2015 / Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure / Stroke 46:1161~1166
Shah AS / 2015 / Short term exposure to air pollution and stroke: systematic review and meta-analysis / BMJ 350:h1295
He M / 2012 / Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumoniae / Toxicol Appl Pharmacol 258:237~247
Yeo NK / 2010 / Asian sand dust enhances rhinovirus-induced cytokine secretion and viral replication in human nasal epithelial cells / Inhal Toxicol 22:1038~1045
Wilker EH / 2015 / Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure / Stroke 46:1161~1166
Shah AS / 2015 / Short term exposure to air pollution and stroke: systematic review and meta-analysis / BMJ 350:h1295
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