지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 251 - 257 (7page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
In this study, the radical scavenging activity and protective effect of ethanol extract from leaf of Engelhardtia chrysolepis HANCE (ECE) against oxidative stress were investigated under in vitro and cellular system. ECE showed strong radical scavenging activities in 1,1-diphenyl-2-picrylhydrazyl, hydroxyl(·OH) and nitric oxide(NO) radical as a concentration-dependent manner. Particularly, strong scavenging activity against the ·OH and NO radical were observed with the IC<SUB>50</SUB> value of 1.30 μg/ml and 12.61 μg/ml, respectively. Furthermore, the cellular oxidative stress was induced by amyloid beta(Aβ<SUB>25-35</SUB>) in C6 glial cells. The treatment of Aβ<SUB>25-35</SUB> to C6 glial cells generated high levels of reactive oxygen specie (ROS) and declined cell viability. However, production of ROS was decreased by the treatment of ECE. In addition, the cell viability was significantly increased at each concentration(10, 25, 50 μg/ml) as dose-dependent manner. The Alzheimer’s disease related protein expressions in Aβ<SUB>25-35</SUB>-treated C6 glial cells were analyzed. The ECE treatment inhibited expression of amyloid precursor protein(APP), Cterminal fragment-β(CTF-β), β-site APP cleaving enzyme(BACE), phosphorylated tau(p-tau) proteins in C6 glial cells induced by Aβ<SUB>25-35</SUB>. The present study indicated that ECE has strong radical scavenging activity and neuroprotective effect through attenuating oxidative stress.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Lim, D. G. / 2004 / Oxidative stress; reactive oxygen species and nitric oxide / Korean J. Crit. Care Med. 19:81~85
Bokov, A. / 2004 / The role of oxidative damage and stress in aging / Mech. Ageing Dev. 125:811~826
김난슬 / 2014 / 하고초(Spica prunellae) 추출물의 항비만 및 산화적 스트레스 억제활성 / 산업식품공학 18(4):413~418
Ricci, J. E. / 2003 / Mitochondrial functions during cell death, a complex (IV)dilemma / Cell Death Differ 10:488~492
Melov, S. / 2000 / Mitochondrial oxidative stress: Physiologic consequences and potential for a role in aging / Ann. NY Acd. Sci. 908:219~225
Bokov, A. / 2004 / The role of oxidative damage and stress in aging / Mech. Ageing Dev. 125:811~826
김난슬 / 2014 / 하고초(Spica prunellae) 추출물의 항비만 및 산화적 스트레스 억제활성 / 산업식품공학 18(4):413~418
Ricci, J. E. / 2003 / Mitochondrial functions during cell death, a complex (IV)dilemma / Cell Death Differ 10:488~492
Melov, S. / 2000 / Mitochondrial oxidative stress: Physiologic consequences and potential for a role in aging / Ann. NY Acd. Sci. 908:219~225
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Neuro-Protective Effect of the Methanolic Extract of Perilla frutescens var. japonica and Rosmarinic Acid against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress in C6 Glial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
Natural Product Sciences
2018 .09
-
The profiles of antioxidant enzyme expression in soleus muscle after atrophic stress
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Reactive Oxygen Species Modulator 1 (ROMO1), a New Potential Target for Cancer Diagnosis and Treatment
전남의대학술지
2019 .01
-
Stress Changes the Spatial Arrangement of Neurons and Glial Cells of Medial Prefrontal Cortex and Sertraline and Curcumin Prevent It
PSYCHIATRY INVESTIGATION
2015 .01
-
Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Kidney Research and Clinical Practice
2021 .01
-
Extracellular matrix from cynomolgus intestine enhance cell proliferation via regulation of Reactive oxidative stress
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Can antioxidants be effective therapeutics for type 2 diabetes?
Journal of Yeungnam Medical Science
2021 .01
-
Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5
The Korean Journal of Physiology & Pharmacology
2017 .05
-
Phagocytic Roles of Glial Cells in Healthy and Diseased Brains
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
The antipsychotic drug pimozide inhibits the human prostate cancer cells through the generation of reactive oxygen species
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Dissociation of mitochondrial reactive oxygen species and skeletal muscle insulin resistance in vivo mouse models
한국실험동물학회 학술발표대회 논문집
2016 .08
-
A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [<sup>11</sup>C]PK11195
Nuclear medicine and molecular imaging : NMMI
2018 .01
-
Caffeic Acid의 항산화 활성 및 Amyloid beta와 LPS에 의한 C6 Glial 세포의 산화적 스트레스 보호 효과
생약학회지(Korean Journal of Pharmacognosy)
2015 .06
-
H<sub>2</sub>O<sub>2</sub> 처리된 LLC-PK₁세포에서 Redox Status 및 NF-κB Signaling에 대한 하고초(夏枯草)의 효과
동의생리병리학회지
2016 .01
-
팔물탕의 항산화 효과와 자외선으로 유도된 각질형성세포 손상에 대한 보호효과
대한예방한의학회지
2015 .12
-
Roles of Reactive Oxygen Species in Rheumatoid Arthritis Pathogenesis
대한류마티스학회지
2016 .01
-
A study on glial scar formation in spinal cord injury model
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Early Postnatal Valproic Acid Exposure Increase the Protein Level of Astrocyte Markers in Frontal Cortex of Rat
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Pretreated duloxetine protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury through decrease of oxidative stress
한국실험동물학회 학술발표대회 논문집
2016 .08
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-518-000069677