지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 1,166 - 1,173 (8page)
- DOI
- 10.4143/crt.2021.091
이용수
초록· 키워드
오류제보하기
Purpose This study aimed to investigate the clinical outcomes with gemcitabine-carboplatin (GCb), the standard treatment for patients with advanced urothelial carcinoma (UC) who are ineligible for cisplatin-based regimens, in advanced UC patients with a glomerular filtration rate (GFR) < 30 mL/min.
Materials and Methods A retrospective cohort study involving GCb-treated advanced UC patients with GFR < 60 mL/min (n=89) was performed. Clinical outcomes were compared between subgroups with GFR < 30 mL/min and GFR ≥ 30 mL/min but < 60 mL/min.
Results Most baseline characteristics were comparable between the two subgroups. Patients with GFR < 30 mL/min had a significantly lower objective response rate (12.5%) compared to those with higher GFR levels (56.7%) (p=0.004). The number of GCb cycles was significantly lower in patients with GFR < 30 mL/min (median 2 cycles) than in those with higher GFR levels (median 6 cycles) (p=0.002). Compared to those with GFR ≥ 30 mL/min but < 60 mL/min, patients with GFR < 30 mL/min showed significantly worse progression-free survival (PFS) and overall survival (OS) (p < 0.001 for both). Further stratification of patient subgroups according to their GFR (i.e., GFR ≥ 45 mL/min but < 60 mL/min vs. GFR ≥ 30 mL/min but < 45 mL/min vs. GFR < 30 mL/min) revealed significantly different PFS and OS (p < 0.001 for both).
Conclusion The use of GCb is discouraged in advanced UC patients with GFR < 30 mL/min. Alternative therapeutic approaches with better efficacy are warranted for these patients.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Koufopoulou M / 2020 / Clinical evidence for the first-line treatment of advanced urothelial carcinoma : current paradigms and emerging treatment options / Cancer Treat Rev 89:102072
von der Maase H / 2000 / Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer : results of a large, randomized, multinational, multicenter, phase III study / J Clin Oncol 18:3068~3077
von der Maase H / 2005 / Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer / J Clin Oncol 23:4602~4608
Bellmunt J / 2017 / Borealis-1 : a randomized, first-line, placebocontrolled, phase II study evaluating apatorsen and chemotherapy for patients with advanced urothelial cancer / Ann Oncol 28:2481~2488
Galsky MD / 2011 / Treatment of patients with metastatic urothelial cancer"unfit"for cisplatin-based chemotherapy / J Clin Oncol 29:2432~2438
von der Maase H / 2000 / Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer : results of a large, randomized, multinational, multicenter, phase III study / J Clin Oncol 18:3068~3077
von der Maase H / 2005 / Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer / J Clin Oncol 23:4602~4608
Bellmunt J / 2017 / Borealis-1 : a randomized, first-line, placebocontrolled, phase II study evaluating apatorsen and chemotherapy for patients with advanced urothelial cancer / Ann Oncol 28:2481~2488
Galsky MD / 2011 / Treatment of patients with metastatic urothelial cancer"unfit"for cisplatin-based chemotherapy / J Clin Oncol 29:2432~2438
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
신장 Depth 측정 방법에 따른 GFR 값의 최적화
핵의학기술
2019 .01
-
Glomerular Filtration Rate 검사방법 및 가이드라인
핵의학기술
2018 .01
-
한국 성인 여성에서 심혈관대사 위험인자와 사구체여과율 저하의 관련성
Korean Journal of Family Practice
2020 .01
-
Initial Preserved Renal Function as a Predictor of Favorable Renal Response to Rituximab in Refractory or Relapsing Lupus Nephritis: A Single-center Cohort Study in Korea
대한류마티스학회지
2022 .01
-
신장과 체중의 변화가 사구체 여과율에 미치는 영향
핵의학기술
2019 .01
-
A prospective study evaluating impact on renal function following percutaneous nephrolithotomy using Tc99m ethylenedicysteine renal scan: Does multiplicity of access tracts play a role?
Investigative and Clinical Urology
2019 .01
-
The effect of long working hours on GFR reduction : The kangbuk Samsung Health Study
대한직업환경의학회 학술대회 논문집
2020 .11
-
Remote Ischemic Conditioning by Effluent Collected from a Novel Isolated Hindlimb Model Reduces Infarct Size in an Isolated Heart Model
Korean Circulation Journal
2017 .01
-
Chronic Kidney Disease and Hepatitis B Virus Surface Antigenemia
Journal of Korean Medical Science
2018 .01
-
추정 사구체여과율의 해석
대한내과학회지
2023 .02
-
Association between renal function, erectile function and coronary artery disease: Detection with coronary angiography
Investigative and Clinical Urology
2015 .01
-
치약용 약효제의 적용시간에 따른 실험실적 효능 연구
치위생과학회지
2016 .01
-
Very low protein diet plus ketoacid analogs of essential amino acids supplement to retard chronic kidney disease progression
Kidney Research and Clinical Practice
2018 .01
-
Treatment of patients with disabilities in pediatric dentistry of Wonju Severance Christian Hospital in Korea
International Journal of Disability and Oral Health
2019 .12
-
Data Science and Machine Learning in Anesthesiology
Korean Journal of Anesthesiology
2020 .01
-
양성자 치료에서 영상 획득 시간에 따른 Off Line PET의 효율성 검증
핵의학기술
2017 .01
-
Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B
Gut and Liver
2020 .01
-
Tenofovir does not induce renal dysfunction compared to entecavir in post-liver-transplant hepatitis B virus patients
Annals of Surgical Treatment and Research
2020 .09
-
Review of Machine Learning Algorithms for Diagnosing Mental Illness
PSYCHIATRY INVESTIGATION
2019 .01
-
Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits
International Neurourology Journal
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0