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논문 기본 정보

자료유형
학술저널
저자정보
김미선 (Department of Internal Medicine Jeju National University Hospital Jeju Korea.Departement of Infecti) 유정래 (제주대학교) 허상택 (제주대학교) 이향란 (Departement of Infectious Control Unit Jeju National University Hospital Jeju Korea.) 오현주 (Department of Internal Medicine Jeju National University Hospital Jeju Korea)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제53권 제4호
발행연도
2021.12
수록면
718 - 729 (12page)
DOI
10.3947/ic.2021.0104

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Background: Jeju island had the seventh highest incidence rate of coronavirus disease 2019 (COVID-19) but showed the lowest case fatality rate among 17 provinces of Korea, which may be associated with comorbidities and geographic differences. This study aimed to analyze the epidemiological and clinical characteristics of patients with COVID-19 and evaluate the risk factors for severe COVID-19 in Jeju island, Korea. Materials and Methods: All patients with COVID-19 admitted between February 20, 2020, and June 19, 2021, at a single center were retrospectively enrolled in this study. The severity of illness was defined using five categories (asymptomatic, mild, moderate, severe, and critical) according to the National Institute of Health criteria. Then, patients with severe and critical illness were grouped into a severe group, whereas patients with asymptomatic, mild, and moderate illness were grouped into a non-severe group. Multivariate logistic regression analysis was performed using risk factors that were found to be significantly associated with the severe group. Results: This study included 348 patients with a median age was 57 years, and 37.5% were aged 60 or older. Among them, 43.4% were male and 10.9% were asymptomatic, whereas 41.4%, 33.9%, 12.9%, and 1.1% had mild, moderate, severe, and critical illness. The all-cause mortality of patients with COVID-19 was 0.28% (1/348). Among confirmed patients with COVID-19, exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was mainly within Jeju island (75.9%). The mean body mass index was 24.09 ± 4.04 kg/m2, the median comorbidity index score was low in each group (0 in asymptomatic; 1 in mild; 1 in moderate; 1 in severe; and 2 in critical group, P <0.548). In the multivariable analysis, male sex [odds ratio (OR), 6.37; 95% confidence interval (CI), 2.69 ? 15.13; P <0.001], ≥65 years of age (OR, 2.68; 95% CI, 1.18 ? 6.10; P <0.019), chronic pulmonary disease (OR, 6.10; 95% CI, 1.40 ? 26.61; P = 0.016), and length of fever duration (OR, 1.33; 95% CI, 1.19 ? 1.49; P <0.001) were independently associated with severe COVID-19. Conclusion: The most relevant risk factors of COVID-19 severity were male sex, older age, underlying chronic lung diseases, and duration of fever during hospitalization. The risk factors for severe COVID-19 were not significantly different from those reported in other studies. However, a lower proportion of the older population among confirmed SARS-CoV-2 cases might contribute to the lower fatality rate than the national rate.
#COVID-19 #SARS-CoV-2 #Korea #Jeju #Mortality

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참고문헌 (24)

참고문헌 신청
Sharma A / 2021 / COVID-19 : A review on the novel coronavirus disease evolution, transmission, detection, control and prevention / Viruses 13:202 google schola 유정래 / 2020 / 코로나바이러스감염증-19의 임상적 특징 / Journal of Medicine and Life Science 17(2):33~40 Crossref World Health Organization (WHO) / Coronavirus disease 2019 (COVID-19) situation report. Coronavirus disease (COVID-19) weekly epidemiological update and weekly operational update google schola Ministry of Health and Welfare (MOHW) / Coronavirus disease-19, Republic of Korea google schola Center for Infection Control / Result of analysis on the status of COVID-19 confirmed cases and source of infection on Jeju island in 2020-2021 google schola

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