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자료유형
학술저널
저자정보
김성우 (대구가톨릭대학교) 전재한 (경북대학교) 문준성 (영남대학교) 김미경 (계명대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.4
발행연도
2021.8
수록면
800 - 809 (10page)
DOI
https://doi.org/10.3803/EnM.2021.1040

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Background: Based on recent evidence on the importance of the presence of diabetes mellitus (DM) and fibrosis-4 (FIB-4) index incoronavirus disease 2019 (COVID-19) mortality, we analyzed whether these factors could additively predict such mortality. Methods: This multicenter observational study included 1,019 adult inpatients admitted to university hospitals in Daegu. The demographic and laboratory findings, mortality, prevalence of severe disease, and duration of quarantine were compared between patientswith and without DM and/or a high FIB-4 index. The mortality risk and corresponding hazard ratio (HR) were analyzed using theKaplan-Meier method and Cox proportional hazard models. Results: The patients with DM (n=217) exhibited significantly higher FIB-4 index and mortality compared to those without DM. Although DM (HR, 2.66; 95% confidence interval [CI], 1.63 to 4.33) and a high FIB-4 index (HR, 4.20; 95% CI, 2.21 to 7.99) wereseparately identified as risk factors for COVID-19 mortality, the patients with both DM and high FIB-4 index had a significantlyhigher mortality (HR, 9.54; 95% CI, 4.11 to 22.15). Higher FIB-4 indices were associated with higher mortality regardless of DM. Ahigh FIB-4 index with DM was more significantly associated with a severe clinical course with mortality (odds ratio, 11.24; 95% CI,5.90 to 21.41) than a low FIB-4 index without DM, followed by a high FIB-4 index alone and DM alone. The duration of quarantineand hospital stay also tended to be longer in those with both DM and high FIB-4 index. Conclusion: Both DM and high FIB-4 index are independent and additive risk factors for COVID-19 mortality.

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