지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,298 - 1,306 (9page)
- DOI
- https://doi.org/10.3803/EnM.2021.1226
이용수
초록· 키워드
오류제보하기
Background: Mitochondrial dysfunction is strongly associated with several kidney diseases. However, no studies have evaluated the potential renal hazards of serum mitochondria-inhibiting substance (MIS) and aryl hydrocarbon receptor ligand (AhRL) levels.
Methods: We used serum level of MIS and AhRL and clinical renal outcomes from 1,511 participants of a prospective communitybased cohort in Ansung. MIS was evaluated based on intracellular adenosine triphosphate (MIS-ATP) or reactive oxygen species (MIS-ROS) generation measured using cell-based assays.
Results: During a mean 6.9-year follow-up, 84 participants (5.6%) developed a rapid decline in kidney function. In the lowest quartile group of MIS-ATP, patients were older and had metabolically deleterious parameters. In multivariate logistic regression analysis, higher MIS-ATP was associated with decreased odds for rapid decline: the odds ratio (OR) of 1% increase was 0.977 (95% confidence interval [CI], 0.957 to 0.998; P=0.031), while higher MIS-ROS was marginally associated with increased odds for rapid decline (OR, 1.014; 95% CI, 0.999 to 1.028; P=0.055). However, serum AhRL was not associated with the rapid decline in kidney function. In subgroup analysis, the renal hazard of MIS was particularly evident in people with hypertension and low baseline kidney function.
Conclusion: Serum MIS was independently associated with a rapid decline in kidney function, while serum AhRL was not. The clinical implication of renal hazard on serum MIS requires further evaluation in future studies.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
이홍규 / 2011 / Mitochondrial Dysfunction and Insulin Resistance: The Contribution of Dioxin-Like Substances / Diabetes and Metabolism Journal 35(3):207~215
Ray PD / 2012 / Reactive oxygen species(ROS)homeostasis and redox regulation in cellular signaling / Cell Signal 24:981~990
Lee HK / 2010 / Mitochondrial dysfunction and metabolic syndrome-looking for environmental factors / Biochim Biophys Acta 1800:282~289
Lowell BB / 2005 / Mitochondrial dysfunction and type 2 diabetes / Science 307:384~387
Bournat JC / 2010 / Mitochondrial dysfunction in obesity / Curr Opin Endocrinol Diabetes Obes 17:446~452
Ray PD / 2012 / Reactive oxygen species(ROS)homeostasis and redox regulation in cellular signaling / Cell Signal 24:981~990
Lee HK / 2010 / Mitochondrial dysfunction and metabolic syndrome-looking for environmental factors / Biochim Biophys Acta 1800:282~289
Lowell BB / 2005 / Mitochondrial dysfunction and type 2 diabetes / Science 307:384~387
Bournat JC / 2010 / Mitochondrial dysfunction in obesity / Curr Opin Endocrinol Diabetes Obes 17:446~452
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