지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: Romosozumab has shown significant improvement in bone mineral density (BMD) in previously reported trials. However, BMD reflects only bone strength and does not offer insight into the bone microarchitecture. The trabecular bone score (TBS) is a non-invasive tool used to assess bone microarchitecture. Several previous studies have evaluated the efficacy of anti-osteoporotic agents using the TBS. However, data regarding the potency of romosozumab based on the TBS is lacking. This retrospective observational cohort study demonstrated the impact of romosozumab use on the TBS. Methods: The primary outcome was the percentage change in the TBS from baseline to post-treatment. Postmenopausal osteoporosis patients were followed up for 6 and 12 months after romosozumab (210 mg monthly, N =10) and denosumab (60 mg every 6 months, N=21) or ibandronate (150 mg monthly, N=24) treatments, respectively. Patients who had previously used osteoporosis medications were included, if any the washout period was sufficient. Results: The percentage change in TBS from baseline to post-treatment was 2.53±2.98% (6 months, N=10; P=0.04), 0.59%±3.26% (12 months, N=21; P=0.48), and -0.45±3.66% (12 months, N=24; P=0.51) in the romosozumab, denosumab, and ibandronate groups, respectively. Romosozumab demonstrated a noticeable increase in TBS, although it did not reach the least significant change (5.8%) in TBS. Conclusions: Romosozumab improved the TBS in postmenopausal women with osteoporosis. TBS may be potentially useful for monitoring romosozumab treatment.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
T.P van Staa / 2001 / Epidemiology of fractures in England and Wales / Bone 29(6):517~522
Felicia Cosman / 2016 / Romosozumab treatment in postmenopausal women with osteoporosis / New England Journal of Medicine 375(16):1532~1543
Michael R. McClung / 2014 / Romosozumab in Postmenopausal Women with Low Bone Mineral Density / New England Journal of Medicine 370(5):412~420
Xiaofeng Li / 2005 / Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling / Journal of Biological Chemistry 280(20):19883~19887
Kenneth G. Saag / 2017 / Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis / New England Journal of Medicine 377(15):1417~1427
Felicia Cosman / 2016 / Romosozumab treatment in postmenopausal women with osteoporosis / New England Journal of Medicine 375(16):1532~1543
Michael R. McClung / 2014 / Romosozumab in Postmenopausal Women with Low Bone Mineral Density / New England Journal of Medicine 370(5):412~420
Xiaofeng Li / 2005 / Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling / Journal of Biological Chemistry 280(20):19883~19887
Kenneth G. Saag / 2017 / Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis / New England Journal of Medicine 377(15):1417~1427
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