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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제19권 제2호
- 발행연도
- 2018.6
- 수록면
- 26 - 31 (6page)
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초록· 키워드
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Actinidia arguta (Actinidiaceae), which is commonly referred to as hardy kiwifruit, has been reported to possess anti-inflammatory, anti-allergic and antioxidative properties. The protective effect of the leaves and stems of A. arguta against amyloid β protein (Aβ) (25-35)-induced cultured neuronal cell death and memory impairment was investigated in the current study. Exposure of cultured cortical neurons to 10 μM Aβ (25-35) for 24 h induced significant neuronal death as assessed by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. However, A. arguta (10 and 50 μg/ml) prevented Aβ (25-35)-induced apoptotic neuronal death in cultured cortical neurons. A. arguta also inhibited the 100 μM H2O2-induced decrease of the MTT reduction rate in cultured neurons. Memory impairment was produced by intracerebroventricular microinjection of 15 nmol Aβ (25-35) and examined using the passive avoidance test in ICR mice. Chronic treatments with A. arguta (50 and 100 mg/kg, 14 days, p.o.) significantly prevented memory impairment induced by Aβ (25-35), and A. arguta inhibited the Aβ (25-35)-induced increase of cholinesterase activity in the brains of memory impaired mice. These results suggest that A. arguta might be able to inhibit Aβ (25-35)-induced neuronal death and memory impairment via antioxidative and anti-cholinesterase effects and that A. arguta could have a therapeutic role for preventing the progression of neurodegeneration in Alzheimer’s disease.
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참고문헌 (37)
참고문헌 신청
Ivins KJ / 1999 / Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid / J Biol Chem 274:2107~2112
Lu P / 2012 / Xanthoceraside attenuates amyloid beta peptide (25-35)-induced learning and memory impairments in mice / Psychopharmacology (Berl) 219:181~190
Sano M / 1997 / A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study / N Engl J Med 336:1216~1222
Gasparini L / 2004 / Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action / J Neurochem 91:521~536
Maurice T / 1996 / Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction / Brain Res 706:181~193
Lu P / 2012 / Xanthoceraside attenuates amyloid beta peptide (25-35)-induced learning and memory impairments in mice / Psychopharmacology (Berl) 219:181~190
Sano M / 1997 / A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study / N Engl J Med 336:1216~1222
Gasparini L / 2004 / Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action / J Neurochem 91:521~536
Maurice T / 1996 / Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction / Brain Res 706:181~193
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