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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제17권 제4호
- 발행연도
- 2016.12
- 수록면
- 109 - 114 (6page)
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초록· 키워드
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Alzheimer’s disease (AD), a progressive neurodegenerative disorder that deprives the patient of memory, is associated mainly with extracellular senile plaque induced by the accumulation of amyloid β protein (Aβ). Silybum marianum (Asteraceae; SM) is a medicinal plant that has long been used in traditional medicine as a hepatoprotective remedy owing to its antioxidant and anti-inflammatory activities. The present study examined the methanol extract of the aerial parts of SM for neuroprotection against Aβ (25-35)-induced neuronal death in cultured rat cortical neurons to investigate a possible therapeutic role of SM in AD. The primary cortical neuron cultures were prepared using embryonic day 15 to 16 SD rat fetuses. Cultured cortical neurons exposed to 10 μM Aβ (25-35) for 36 h underwent neuronal cell death. At 10 and 50 μg/mL, SM prevented Aβ (25-35)-induced neuronal cell death and apoptosis in cultured cortical neurons. Furthermore, SM inhibited the Aβ (25-35)-induced decrease in anti-apoptotic protein, Bcl-2, and the increase in the pro-apoptotic proteins, Bax and active caspase-3. Cultured cortical neurons exposed to 1 mM N-methyl-D-aspartate (NMDA) for 14 h induced neuronal cell death. SM (10 and 50 μg/mL) prevented NMDA-induced neuronal cell death. These results suggest that SM inhibited Aβ (25-35)-induced neuronal apoptotic death via inhibition of NMDA receptor activation and that SM has a possible therapeutic role in preventing the progression of neurodegeneration in AD.
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참고문헌 (35)
참고문헌 신청
Selkoe DJ / 2001 / Alzheimer's disease : genes, proteins, and therapy / Physiol Rev 81:741~766
Butterfield DA / 2001 / Evidence of oxidative damage in Alzheimer's disease brain : central role for amyloid beta-peptide / Trends Mol Med 7:548~554
Mattson MP / 2003 / Neuronal and glial calcium signaling in Alzheimer's disease / Cell Calcium 34:385~397
Parks JK / 2001 / Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro / J Neurochem 76:1050~1056
Gitter BD / 1995 / Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells / Proc Natl Acad Sci U S A 92:10738~10741
Butterfield DA / 2001 / Evidence of oxidative damage in Alzheimer's disease brain : central role for amyloid beta-peptide / Trends Mol Med 7:548~554
Mattson MP / 2003 / Neuronal and glial calcium signaling in Alzheimer's disease / Cell Calcium 34:385~397
Parks JK / 2001 / Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro / J Neurochem 76:1050~1056
Gitter BD / 1995 / Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells / Proc Natl Acad Sci U S A 92:10738~10741
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