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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제4호
- 발행연도
- 2016.7
- 수록면
- 347 - 355 (9page)
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초록· 키워드
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Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor alpha (TNF-α) induced lectin-like receptor for oxidized low density lipoprotein (LOX-1) were investigated. Human umbilical vein endothelial cells (HUVECs) were cultured and the effect of TNF-α on LOX-1 expression at mRNA and protein levels was determined by Real-time PCR and Western blotting respectively. The formation of intracellular ROS was determined with fluorescence probe CM-DCFH2-DA. The endothelial ox-LDL uptake was evaluated with DiI-ox-LDL. The effect of CPT on LOX-1 expression was also evaluated with SD rats. TNF-α induced LOX-1 expression in a dose- and time- dependent manner in endothelial cells. TNF-α induced ROS formation, phosphorylation of NF-κB p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT. NF-κB inhibitor BAY11-7082 and ERK inhibitor PD98059 inhibited TNF-α-induced LOX-1 expression. CPT and NAC suppressed TNF-α-induced LOX-1 expression and phosphorylation of NF-κB p65 and ERK in rat aorta. These data suggested that TNF-α induced LOX-1 expression via ROS activated NF-κB/ERK pathway, which could be inhibited by CPT. This study provides new insights for the anti-atherosclerotic effect of CPT.
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참고문헌 (38)
참고문헌 신청
Yagi A / 1989 / Possible active components of tan-shen(Salvia miltiorrhiza)for protection of the myocardium against ischemia-induced derangements / Planta Med 55:51~54
Ma S / 2012 / Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metalloproteinase-2 / Mol Med Rep 6:145~150
Jin HJ / 2013 / TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2cells / PLoS One 8:51720
Suh SJ / 2006 / Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-alphainduced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-kappaB and AP-1 / Biochem Pharmacol 72:1680~1689
Zhou Z / 2006 / Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells / Biochim Biophys Acta 1760:1~9
Ma S / 2012 / Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metalloproteinase-2 / Mol Med Rep 6:145~150
Jin HJ / 2013 / TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2cells / PLoS One 8:51720
Suh SJ / 2006 / Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-alphainduced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-kappaB and AP-1 / Biochem Pharmacol 72:1680~1689
Zhou Z / 2006 / Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells / Biochim Biophys Acta 1760:1~9
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