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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. Allium tuberosum (AT), which is used as a functional food, has a thrombolytic effect. It contains vitamin A, vitamin C, carbohydrate, calcium, iron, and phosphorus. There are many carotenes that turn into vitamin A in the body. Also, it helps blood circulation and stimulates metabolism. The purpose of the this study was to estimate the anti-inflammatory effects of the AT extract. Methods: Human vascular endothelial cells were pre-treated with 100 microgram/mL AT extract for 30 minutes and subsequently co-treated with TNF-alpha (10 ng/mL) and AT extract (100 microgram/mL) for 1, 4, and 6 hours. After treatment, the cells were lysed and used for quantitative reverse transcription PCR, Western blot analysis, and monocyte adhesion assay. Results: We examined the effect of the AT extract on inflammatory gene expression in TNF-alpha-induced human umbilical vein endothelial cells (HUVECs). The extract reduced the expression levels of mRNA and protein of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in TNF-alpha-stimulated HUVECs. It also inhibited the TNF-alpha-induced phosphorylation of the NF-kappaB p65 subunit and degradation of IkappaBalpha. Furthermore, the AT extract prevented the increased adhesion capacity of monocyte to TNF-alpha-stimulated vascular endothelial cells by reducing ICAM-1 and VCAM-1 expression. Conclusions: The AT extract has preventive and anti-inflammatory effect against vascular disease and has potential for supporting prevention against the early process of atherosclerosis.
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참고문헌 (15)
참고문헌 신청
한상현 / 2015 / Two new phenylpropane glycosides from Allium tuberosum Rottler / Archives of Pharmacal Research 38(7):1312~1316
Zeng Y / 2017 / Therapeutic role of functional components in alliums for preventive chronic disease in human being / Evid Based Complement Alternat Med 2017:9402849
Sprague AH / 2009 / Inflammatory cytokines in vascular dysfunction and vascular disease / Biochem Pharmacol 78:539~552
McHale JF / 1999 / Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha / J Immunol 162:1648~1655
Chan SC / 2008 / Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis / Respir Med 102:287~298
Zeng Y / 2017 / Therapeutic role of functional components in alliums for preventive chronic disease in human being / Evid Based Complement Alternat Med 2017:9402849
Sprague AH / 2009 / Inflammatory cytokines in vascular dysfunction and vascular disease / Biochem Pharmacol 78:539~552
McHale JF / 1999 / Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha / J Immunol 162:1648~1655
Chan SC / 2008 / Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis / Respir Med 102:287~298
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