지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 514 - 528 (15page)
이용수
초록· 키워드
오류제보하기
Objective: To examine the effects of Trichosanthes kirilowii Maximowicz extract (TE) and Trichosanthes kirilowii Maxi mowicz Cheonghyeol Plus Phellinus linteus Cheonghyeol plus (TCP) on anti-inflammatory factor expression in human umbilical vein endothelial cells (HUVECs).
Methods: HUVECs were activated with TNF-α and then treated with TE and TCP. The expression levels were then measured for intracellular genes (KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1), proteins (KLF2, eNOS, MCP-1, ICAM-1, VCAM-1, ERK, and JNK, p38), and extracellular biomarkers (ICAM-1, VCAM-1, and MCP-1).
Results: 1. TCP at concentrations of 100 μg/mL or greater significantly increased the expression of KLF2 and eNOS intracellular genes and significantly decreased the expression of ICAM-1, VCAM-1, and MCP-1 genes compared to the control group.
2. TCP at concentrations of 100 μg/mL or greater significantly increased the expression of KLF2, eNOS proteins compared to the control group, and significantly reduced the expression of VCAM-1, ICAM-1, MCP-1, ERK, and p38 proteins. However, JNK protein phosphorylation showed no significant change compared to the control group.
3. TCP at concentrations of 100 μg/mL or more significantly decreased the production of MCP-1, ICAM-1, and VCAM-1 extracellular biomarkers compared to the control group.
4. TE at a concentration of 100 μg/mL did not cause any significant change in the expression of intracellular genes or proteins, in the production of the extracellular biomarker MCP-1, or in the amount of JNK protein compared to the control group. Other intracellular genes, proteins, and extracellular biomarker expression showed the same trend as observed with TCP exposure.
Conclusion: This study experimentally confirmed that TE and TCP could be effective in preventing or inhibiting various inflammatory vascular diseases due to their anti-inflammatory effects.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
금은화가 HUVEC에서 죽상동맥경화증 관련 염증인자 발현 억제에 미치는 영향
대한한방내과학회지
2021 .01
-
인간 제대정맥 내피세포에서 산수유와 산수유청혈플러스의 항염증효과
대한한의학회지
2022 .09
-
葛根黃蓮黃芩湯과 疎風活血湯이 HUVEC 내에 MCP-1, ICAM-1, VCAM-1 and eNOS의 유전자 발현량에 대해 미치는 영향
대한한방내과학회지
2020 .01
-
오가피청혈플러스가 NF-κB 및 MAPKs 신호전달체계와 혈관부착인자 등에 미치는 영향
대한한방내과학회지
2020 .01
-
상황청혈플러스(PLCP)가 HUVEC에서 이상지질혈증 관련 항산화 작용 및 염증인자 발현 억제에 미치는 영향
대한한의학회지
2020 .06
-
청혈플러스가 혈관내피세포에서 염증 지표인자에 미치는 영향
혜화의학회지
2018 .01
-
Protective Effect of Allium tuberosum Extract on Vascular Inflammation in Tumor Necrosis Factor-alpha-induced Human Vascular Endothelial Cells
대한암예방학회지
2017 .01
-
해백청혈플러스(AMCP)의 항산화 및 항염증 작용을 통한 죽상동맥경화 억제 효과
동의생리병리학회지
2020 .06
-
인간 혈관 내피세포에서 NF-κB 억제를 통한 엉겅퀴 추출물의 VCAM-1 및 ICAM-1 발현 억제효과
생약학회지(Korean Journal of Pharmacognosy)
2023 .03
-
Immunohistochemical Evaluation of Angiogenesis Related Markers in Pyogenic Granuloma of Gingiva
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Cell proliferating responses to magnesium coated β-TCP surface
Oral Biology Research
2016 .01
-
Adipose-Derived Stem Cell Transplantation Inhibits Vascular Inflammatory Responses and Endothelial Dysfunction in Rats with Atherosclerosis
Yonsei Medical Journal
2019 .01
-
하늘타리(Trichosanthes kirilowii Maxim.) 부위별 추출물의 항산화 및 항염증 활성
생약학회지(Korean Journal of Pharmacognosy)
2016 .12
-
Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors
Clinical and Experimental Emergency Medicine
2018 .01
-
Decreased Serum Monocyte Chemoattractant Protein-1 in Salivary Gland Tumor Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Preliminary Findings on the Effectiveness of Meaning-Centered Psychotherapy in Patients with Pancreatobiliary Cancer
Yonsei Medical Journal
2018 .01
-
Epigallocatechin-3-gallate 함유 β-TCP이식재의 골재생능에 관한 조직계측학적 평가
대한치과재료학회지
2018 .09
-
Regulation of vascular smooth muscle phenotype by crossregulation of kruppel-like factors
The Korean Journal of Physiology & Pharmacology
2017 .01
-
Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women
Journal of Obesity & Metabolic Syndrome
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0