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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 21 - 27 (7page)
- DOI
- http://dx.doi.org/10.5230/jgc.2016.16.1.21
이용수
초록· 키워드
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Purpose: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients.
Materials and Methods: Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009.
Results: In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022). In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates.
Conclusions: We suggested that TLE1 expression is a good prognostic indicator in GCs.
목차
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참고문헌 (22)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Chen G / 2000 / Groucho/TLE family proteins and transcriptional repression / Gene 249:1~16
Arce L / 2009 / Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression / BMC Cancer 9:159
Ghosh HS / 2007 / Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription / Biochem J 408:105~111
Buscarlet M / 2009 / Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1 / PLoS One 4:e8107
Chen G / 2000 / Groucho/TLE family proteins and transcriptional repression / Gene 249:1~16
Arce L / 2009 / Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression / BMC Cancer 9:159
Ghosh HS / 2007 / Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription / Biochem J 408:105~111
Buscarlet M / 2009 / Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1 / PLoS One 4:e8107
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