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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.4
- 수록면
- 107 - 115 (9page)
- DOI
- 10.7783/KJMCS.2023.31.2.107
이용수
초록· 키워드
오류제보하기
Background: Identifying new natural products to controlling inflammatory responses involved in screening of Asian native plants. The screening revealed a potential candidate, Amomum muricarpum Elmer, which is a traditional medicinal plant for gastrointestinal diseases in Vietnam; however, its scientific basis remains unknown, its scientific basis remain unknown.
Methods and Results: A. muricarpum extract suppressed lipopolysaccharide (LPS)-induced the protein expression of inflammatory mediators such as interleukine (IL)-1β and cyclooxygenase-2 in mouse-derived RAW264.7 macrophages. The mRNA expression levels of IL-6, IL-1β, tumor necrosis factor-α, and inducible nitric oxide synthase in response to LPS were reduced by A. muricarpum extract. Additionally, A. muricarpum extract inhibited phosphorylation of the signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB). This result indicates A. muricarpum suppressed the expression of inflammatory cytokines and mediators by inhibiting signal transducer and STAT3 and NF-κB activation.
Conclusions: This is the first scientific evidence to report that A. muricarpum suppresses inflammatory signaling pathways and can potentially manage excessive and chronic inflammatory responses.
Methods and Results: A. muricarpum extract suppressed lipopolysaccharide (LPS)-induced the protein expression of inflammatory mediators such as interleukine (IL)-1β and cyclooxygenase-2 in mouse-derived RAW264.7 macrophages. The mRNA expression levels of IL-6, IL-1β, tumor necrosis factor-α, and inducible nitric oxide synthase in response to LPS were reduced by A. muricarpum extract. Additionally, A. muricarpum extract inhibited phosphorylation of the signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB). This result indicates A. muricarpum suppressed the expression of inflammatory cytokines and mediators by inhibiting signal transducer and STAT3 and NF-κB activation.
Conclusions: This is the first scientific evidence to report that A. muricarpum suppresses inflammatory signaling pathways and can potentially manage excessive and chronic inflammatory responses.
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ABSTRACT
서언
재료 및 방법
결과
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UCI(KEPA) : I410-ECN-0101-2023-524-001405588