지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), a structural analog of adenosine monophosphate (AMP), promotes oxidative remodeling in muscle cells. AICAR activates AMP-dependent protein kinase (AMPK), thus increasing lipid metabolism, respiration, and mitochondrial counts. This process is called oxidative remodeling, which enhances the physical endurance of mice. To test this drug on an invertebrate that is genetically similar to humans, we used the small water crustacean Daphnia magna, which is sensitive to changes in water conditions. We tested the effects of pH on the efficacy of AICAR using two methods. One method measured oxygen consumption of Daphnia in oxygen chambers. The other method determined lipid levels of Daphnia through fluorescent tagging of lipids. The results showed that when exposed to AICAR at pH 6.58, D. magna consumed more oxygen and had lower overall levels of lipids, which is consistent with the expected effects of AICAR, such as increased respiration and lipid metabolism.
목차
ABSTRACT
INTRODUCTION
EXPERIMENTAL
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
마우스 C2C12 근관세포에서 AICAR로 유도된 근위축에 미치는 오미자 추출물의 영향
생명과학회지
2015 .03
-
C2C12 근관세포에서 상엽에 의한 AMPK의 불활성화와 AICAR로 유도된 근위축 억제의 연관성에 관한 연구
생명과학회지
2018 .04
-
물벼룩 (Daphnia magna)에서 내분비계장애물질인 노닐페놀의 영향
환경생물
2015 .01
-
Proteomic profiles of Daphnia magna exposed to lead (II) acetate trihydrate and atrazine
Genes & Genomics
2017 .01
-
The Role of Three Galactolipids Synthase Gene in Microalgal Lipid Turn-over from Membrane Lipid to Neutral Lipid
한국미생물학회 학술대회논문집
2019 .04
-
화학물질에 대한 독성시험 bi-trophic microcosm 구축에 있어 표준시험생물 녹조류 (Pseudokirchneriella subcapitata)와 물벼룩 (Daphnia magna)의 개체군 특성 연구
생태와 환경
2016 .01
-
Optimization for Scenedesmus obliquus Cultivation: the Effects of Temperature, Light Intensity and pH on Growth and Biochemical Composition
한국미생물·생명공학회지
2019 .01
-
포식성 천적생물을 이용한 친환경 유해조류 제어기술 개발
환경생물
2016 .01
-
A fluorescence study of flip-flop rate of lipid molecules in lipid vesicles
한국분석과학회 학술대회
2017 .11
-
Enhanced Lipid Production of Chlorella sp. HS2 Using Serial Optimization and Heat Shock
Journal of Microbiology and Biotechnology
2020 .01
-
Effects of quercetin derivatives from mulberry leaves : Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice
Nutrition Research and Practice
2015 .04
-
Effects of quercetin derivatives from mulberry leaves : Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice
Nutrition Research and Practice
2015 .04
-
A Study on the Flip-flop Movement of Lipid Molecules at the Hydration Levels of Lipid Multi bilayers
한국분석과학회 학술대회
2019 .11
-
Easy and rapid quantification of lipid contents of marine dinoflagellates using the sulpho-phospho-vanillin method
Algae
2016 .01
-
A Comprehensive Understanding of Model Lipid Membranes: Concepts to Applications
대한화학회지
2023 .04
-
Daphnia magna와 Euglena agilis를 이용한 도금폐수 독성평가
환경생물
2016 .01
-
Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis : a double blind placebo controlled study
Nutrition Research and Practice
2015 .04
-
Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis : a double blind placebo controlled study
Nutrition Research and Practice
2015 .04
-
Immune Enhancement Effects of Neutral Lipids, Glycolipids, Phospholipids from Halocynthia aurantium Tunic on RAW264.7 Macrophages
Journal of Microbiology and Biotechnology
2024 .02
-
Crystallization and X-ray crystallographic analysis of the PH-like domain of lipid transfer protein anchored at membrane contact sites from Saccharomyces cerevisiae
Biodesign
2017 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0