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논문 기본 정보

자료유형
학술저널
저자정보
Jo Seon Ha (Department of Nano Bio Engineering Seoul National University of Science and Technology Seoul 01811 Republic of Korea) Kim Kyeong Jin (Department of Nano Bio Engineering Seoul National University of Science and Technology Seoul 01811 Republic of Korea) Park Soo-yeon (Department of Food Science and Technology Seoul National University of Science and Technology Seoul 01811 Republic of Korea) Paik Hyun-Dong (Department of Food Science and Biotechnology of Animal Resources Konkuk University Seoul 05029 Republic of Korea) Kim Ji Yeon (Department of Nano Bio Engineering Seoul National University of Science and Technology Seoul 01811 Republic of KoreaDepartment of Food Science and Technology Seoul National University of Science and T)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제3호
발행연도
2023.3
수록면
356 - 362 (7page)
DOI
10.4014/jmb.2211.11049

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The 2'-fucosyllactose (2'-FL) is the richest components in a human milk oligosaccharide. Several studies have reported that 2'-FL has beneficial effects in infants. However, there are few studies on its immune-enhancing effects. This research aimed to examine the immune-enhancing effect of 2'- FL on immunosuppression by cyclophosphamide (CCP) in ICR mice. Mice were orally administered distilled water or 0.5 mg/kg B.W. 2'-FL for 14 days. An immunocompromised mouse model was induced using CCP 80 mg/kg B.W. at 12-14 days. Using the CCP had effects on reducing their body weight, organ weight, spleen index, natural killer (NK) cell activity, and cytokines concentration and expression. This study also used concanavalin A-mediated T-cell proliferation to verify the immuneenhancing effects in the sample. Body weight, spleen index, organ weight, and cytokine levels were measured to estimate the immune-enhancing effects. The body weight at 14 days tended to increase, and the spleen weight and index significantly increased in the 2'-FL group compared to the CCP group. The NK cell activity increased in the 2'-FL group compared to the CCP group, but there was no significant difference. The concentration of interleukin (IL)-2 tended to recover in the 2'-FL group compared to the CCP group. The 2'-FL group showed a significant increase of IL-10 and IFNgamma concentration compared to the CCP group. In addition, there was a trend of increased IL-10 mRNA expression compared to the CCP group. These results revealed that 2'-FL improved CCPinduced immunosuppression, suggesting that 2'-FL may have the potential to enhance the immune system.

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