개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 199 - 207 (9page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Fermented Laminaria japonica (FL), a type sea tangle used as a functional food ingredient, has been reported to possess cognitive improving properties that may aid in the treatment of common neurodegenerative disorders, such as dementia.
MATERIALS/METHODS: We examined the effects of FL on scopolamine (Sco)- and ethanol (EtOH)-induced hippocampus-dependent memory impairment, using the Passive avoidance (PA) and Morris water maze (MWM) tests. To examine the underlying mechanisms associated with neuroprotective effects, we analyzed acetylcholine (ACh) and acetylcholinesterase (AChE) activity, brain tissue expression of muscarinic acetylcholine receptor (mAChR), cAMP response element binding protein (CREB) and extracellular signal-regulated kinases 1/2 (ERK1/2), and immunohistochemical analysis, in the hippocampus of mice, compared to current drug therapy intervention. Biochemical blood analysis was carried out to determine the effects of FL on alanine transaminase (ALT), aspartate transaminase (AST), and triglyceride (TG) and total cholesterol (TC) levels. 7 groups (n = 10) consisted of a control (CON), 3 Sco-induced dementia and 3 EtOH-induced dementia groups, with both dementia group types containing an untreated group (Sco and EtOH); a positive control, orally administered donepezil (Dpz) (4㎎/㎏) (Sco + Dpz and EtOH + Dpz); and an FL (50 ㎎/㎏) treatment group (Sco + FL50 and EtOH + FL50), orally administered over the 4-week experimental period.
RESULTS: FL50 significantly reduced EtOH-induced increase in AST and ALT levels. FL50 treatment reduced EtOH-impaired step-through latency time in the PA test, and Sco- and EtOH-induced dementia escape latency times in the MWM test. Moreover, anticholinergic effects of Sco and EtOH on the brain were reversed by FL50, through the attenuation of AChE activity and elevation of ACh concentration. FL50 elevated ERK1/2 protein expression and increased p-CREB (ser133) in hippocampus brain tissue, according to Western blot and immunohistochemistry analysis, respectively.
CONCLUSION: Overall, these results suggest that FL may be considered an efficacious intervention for Sco- and EtOH-induced dementia, in terms of reversing cognitive impairment and neuroplastic dysfunction.
MATERIALS/METHODS: We examined the effects of FL on scopolamine (Sco)- and ethanol (EtOH)-induced hippocampus-dependent memory impairment, using the Passive avoidance (PA) and Morris water maze (MWM) tests. To examine the underlying mechanisms associated with neuroprotective effects, we analyzed acetylcholine (ACh) and acetylcholinesterase (AChE) activity, brain tissue expression of muscarinic acetylcholine receptor (mAChR), cAMP response element binding protein (CREB) and extracellular signal-regulated kinases 1/2 (ERK1/2), and immunohistochemical analysis, in the hippocampus of mice, compared to current drug therapy intervention. Biochemical blood analysis was carried out to determine the effects of FL on alanine transaminase (ALT), aspartate transaminase (AST), and triglyceride (TG) and total cholesterol (TC) levels. 7 groups (n = 10) consisted of a control (CON), 3 Sco-induced dementia and 3 EtOH-induced dementia groups, with both dementia group types containing an untreated group (Sco and EtOH); a positive control, orally administered donepezil (Dpz) (4㎎/㎏) (Sco + Dpz and EtOH + Dpz); and an FL (50 ㎎/㎏) treatment group (Sco + FL50 and EtOH + FL50), orally administered over the 4-week experimental period.
RESULTS: FL50 significantly reduced EtOH-induced increase in AST and ALT levels. FL50 treatment reduced EtOH-impaired step-through latency time in the PA test, and Sco- and EtOH-induced dementia escape latency times in the MWM test. Moreover, anticholinergic effects of Sco and EtOH on the brain were reversed by FL50, through the attenuation of AChE activity and elevation of ACh concentration. FL50 elevated ERK1/2 protein expression and increased p-CREB (ser133) in hippocampus brain tissue, according to Western blot and immunohistochemistry analysis, respectively.
CONCLUSION: Overall, these results suggest that FL may be considered an efficacious intervention for Sco- and EtOH-induced dementia, in terms of reversing cognitive impairment and neuroplastic dysfunction.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine- and ethanol-induced dementia model mice
Nutrition Research and Practice
2018 .06
-
푸드 리터러시에 대한 개념 정립과 적용 방안 모색: 주제범위 문헌고찰을 통하여
대한지역사회영양학회지
2021 .04
-
The level of food literacy and its association with food intake and obesity status among Seoul citizens: results from Seoul Food Survey 2021
Nutrition Research and Practice
2023 .10
-
The level of food literacy and its association with food intake and obesity status among Seoul citizens: results from Seoul Food Survey 2021
Nutrition Research and Practice
2023 .10
-
Evaluating the effectiveness of a food literacy pilot program for university students: using a mixed-methods research approach
Nutrition Research and Practice
2024 .12
-
Evaluating the effectiveness of a food literacy pilot program for university students: using a mixed-methods research approach
Nutrition Research and Practice
2024 .12
-
The Human Milk Oligosaccharide 2'-Fucosyllactose Shows an Immune-Enhancing Effect in a Cyclophosphamide-Induced Mouse Model
Journal of Microbiology and Biotechnology
2023 .03
-
Development of a campus-based intervention program to strengthen food literacy among university students: A qualitative formative study
대한지역사회영양학회지
2023 .12
-
로즈마리(Rosmarinus officinalis L.) 극성별 용매 추출물의 생리활성 검증
생명과학회지
2019 .01
-
The effect of curcumin on blood pressure and cognitive impairment in spontaneously hypertensive rats
Nutrition Research and Practice
2023 .04
-
The effect of curcumin on blood pressure and cognitive impairment in spontaneously hypertensive rats
Nutrition Research and Practice
2023 .04
-
만성 알코올과 철분의 과잉 섭취가 흰쥐의 간 세포 미토콘드리아 DNA 손상에 미치는 영향
Journal of Nutrition and Health
2015 .10
-
SCO6992, a Protein with β-Glucuronidase Activity, Complements a Mutation at the absR Locus and Promotes Antibiotic Biosynthesis in Streptomyces coelicolor
Journal of Microbiology and Biotechnology
2021 .11
-
백금 담지 촉매상에서 에탄올의 저온연소
한국환경과학회지
2017 .01
-
Antioxidant Activities of Powdered and Ultra-fine Powdered Ulmus Davidiana var. Japonica
한국지역사회생활과학회지
2016 .08
-
MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis
Molecules and Cells
2016 .08
-
Targeting of CYP2E1 by miRNAs in alcohol-induced intestine injury
Molecules and Cells
2024 .01
-
LuxR-Type SCO6993 Negatively Regulates Antibiotic Production at the Transcriptional Stage by Binding to Promoters of Pathway-Specific Regulatory Genes in Streptomyces coelicolor
Journal of Microbiology and Biotechnology
2022 .09
-
A re-evaluation of assumptions : FL used in dinosaurian speed prediction from trackways
한국고생물학회 정기총회 및 학술발표회
2015 .02
-
Change in ethanol and alcohol biomarker (EtG, EtS) under baterical conditions
한국분석과학회 학술대회
2021 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-594-002217025