지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.1
- 수록면
- 1 - 13 (13page)
- DOI
- https://doi.org/10.3802/jgo.2023.34.e2
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초록· 키워드
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Objective: To identif y candidate predictors for the prognosis of cer vical intraepithelialneoplasia 2 (CIN2) lesions and evaluate the prognostic value of the local immune response.
Methods: One hundred fifteen CIN2 patients were enrolled. The percentage of p16-,minichromosome maintenance complex component 2- or apolipoprotein B mRNAediting enzyme catalytic subunit 3G (APOBEC3G)-positive cells was determinedimmunohistochemically. Tumor-infiltrating lymphocytes (TILs) in intertumoral lesionswere scored using an automated system. CIN3 disease progression and regression rateswere estimated by the Kaplan–Meier method. A case-control study was conducted to screenCIN2 prognostic factors in 10 regression and 10 progression patients. Selected factors wereexamined in a cohort study to determine their prognostic value for CIN2.
Results: Among all participants, the cumulative progression and regression rates at 60months were 0.477 and 0.510, respectively. In the case-control study, p16- and APOBEC3G-positive cells were higher in the progression group (p=0.043, p=0.023). Additionally, CD4+cell infiltration was enhanced in the regression group (p=0.023). The cohort study revealed asignificantly increased progression rate in patients with elevated p16-positive cells (p<0.001),and increased CD4+ TIL infiltration was associated with better regression (p=0.011). Kaplan–Meier analysis according to human papillomavirus (HPV) positivity revealed a greaterCIN3 development risk in HPV16-positive patients than in HPV16-negative cases. Finally,multivariate analysis identified HPV16 infection and CD4+ TIL infiltration as independentprognostic factors in CIN2 regression.
Conclusion: CD4+ TIL infiltration in intertumoral lesions was related with CIN2 regression.
Our findings suggest CD4+ TIL infiltration may be useful for the triage of CIN2 patients.
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