지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.2
- 수록면
- 98 - 103 (6page)
- DOI
- https://doi.org/10.5483/BMBRep.2023-0187
이용수
초록· 키워드
오류제보하기
The mammalian sirtuin family (SIRT1–SIRT7) has shown diver se biological roles in the regulation and maintenance of ge nome stability under genotoxic stress. SIRT7, one of the leaststudied sirtuin, has been demonstrated to be a key factor forDNA damage response (DDR). However, conflicting resultshave proposed that Sirt7 is an oncogenic factor to promotetransformation in cancer cells. To address this inconsistency, weinvestigated properties of SIRT7 in hepatocellular carcinoma(HCC) regulation under DNA damage and found that loss ofhepatic Sirt7 accelerated HCC progression. Specifically, thenumber, size, and volume of hepatic tumor colonies in diethyl nitrosamine (DEN) injected Sirt7-deficient liver were markedlyenhanced. Further, levels of HCC progression markers andpro-inflammatory cytokines were significantly elevated in theabsence of hepatic Sirt7, unlike those in the control. In chro matin, SIRT7 was stabilized and colocalized to damage site byinhibiting the induction of γH2AX under DNA damage. Toge ther, our findings suggest that SIRT7 is a crucial factor for DNAdamage repair and that hepatic loss-of-Sirt7 can promote ge nomic instability and accelerate HCC development, unlike earlystudies describing that Sirt7 is an oncogenic factor.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MDM2-dependent Sirt1 degradation is a prerequisite for Sirt6-mediated cell death in head and neck cancers
Experimental and Molecular Medicine
2021 .03
-
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation
BMB Reports
2019 .01
-
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
Experimental and Molecular Medicine
2021 .09
-
SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence
Experimental and Molecular Medicine
2023 .06
-
SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes
Experimental and Molecular Medicine
2019 .01
-
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
Experimental and Molecular Medicine
2024 .03
-
Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response
Experimental and Molecular Medicine
2019 .01
-
Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans
Experimental and Molecular Medicine
2019 .01
-
Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting
Experimental and Molecular Medicine
2021 .09
-
KSY-PH1 Prevents UVB-Induced Damage and Promotes Wound Healing In Skin Cells via Coregulation of Sirt1 and Pin1
한국생물공학회 학술대회
2015 .04
-
Hepatocellular carcinoma: old friends and new tricks
Experimental and Molecular Medicine
2020 .12
-
Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging
BMB Reports
2019 .01
-
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
Experimental and Molecular Medicine
2019 .01
-
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis
Experimental and Molecular Medicine
2023 .01
-
Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulatingdendritic cell maturation
Experimental and Molecular Medicine
2016 .01
-
Astrocytic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Extremely Low Frequency Electromagnetic Field through Modulating SIRT1
한국생물공학회 학술대회
2015 .04
-
Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis
Experimental and Molecular Medicine
2019 .01
-
Suppression of SIRT2 and altered acetylation status of human pluripotent stem cells: possible link to metabolic switch during reprogramming
BMB Reports
2017 .01
최근 본 자료
댓글(0)
0