지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation Vol.54 No.2
- 발행연도
- 2024.3
- 수록면
- 229 - 247 (19page)
- DOI
- 10.1007/s40005-023-00660-9
이용수
초록· 키워드
오류제보하기
Purpose A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information.
Methods Drug-in-adhesive patches were fabricated using a micrometer-adjustable film applicator. The applied Design of Experiments (DoE) approach consisted of the Fractional Factorial Resolution V + design and the Central Composite Face design established by the MODDE® 12.0 software. Molecular-level drug-excipient interactions were investigated using infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. The effects on skin physiological function was assessed using DermaLab Combo.
Results DoE results revealed that TEA enhanced flux by 3.14-fold, whereas RH40 reduced it by 4.62-fold. The addition of RH40 resulted in the disappearance of the proton peak within the region of 12–13 ppm, suggesting competition for hydrogen bonding with LOR between TEA and RH40. The optimized formulation (4% TEA, 0% RH40, and 0.2% Al(OH)3) increased skin hydration by 6.20-fold. Opposing effects of TEA and RH40 on skin elasticity were observed.
Conclusion Expected flux and adhesion strength for the optimized formulation were 7.18 μg·cm–2·h–1 and 11.79 mJ, respectively.
Our understanding of the conflicting effects of TEA and RH40 has been advanced. The integrated use of the two-step DoE, physicochemical studies, and skin physiology assessments was proven to be effective in elucidating the simultaneous effects of different permeation-modifying strategies on patches, thus having substantial value for the successful execution of future research endeavors.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
Journal of Ginseng Research
2017 .07
-
The molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on anti-angiogenesis in cancer treatment: The battle between PI3K and ROS
Journal of Ginseng Research
2025 .03
-
(20s) Ginsenoside Rh2 suppress colorectal cancer cell growth by Axl signal pathway in vitro and in vivo
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Perioperative and Long-Term Oncological Outcomes of Laparoscopic RH with Comparison to Open RH
대한외과학회 학술대회 초록집
2023 .05
-
Rh 항원 부적합 적혈구 수혈에 의한 동종면역 발생의 확인
대한수혈학회지
2020 .01
-
Suppression effect of the 20(S)-ginsenoside Rh2 in oral cancer cell growth
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
Journal of Ginseng Research
2021 .01
-
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-kB and MAPK-Nrf2/NF-kB pathways
Journal of Ginseng Research
2022 .07
-
20(S)-ginsenoside Rh2 inhibits colorectal cancer cell proliferation, migration, and invasion through suppressing Axl signaling pathway
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells
Journal of Ginseng Research
2018 .10
-
Ginsenoside Rh2 differentially Mediates microRNA Expression to Prevent Chemoresistance of Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts
Journal of Ginseng Research
2022 .09
-
Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism
Journal of Pharmaceutical Investigation
2022 .01
-
Protective effect of ginsenoside Rh3 against anticancer drug-induced apoptosis in LLC-PK1 kidney cells
Journal of Ginseng Research
2017 .04
-
20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo
Journal of Ginseng Research
2022 .05
-
Rh2-enriched Korean Ginseng Ameliorates Chronic Fatigue in a Forced Exercise mouse model
대한한의학회지
2016 .06
-
Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation
Journal of Ginseng Research
2021 .11
-
Evaluation of maternal rhesus blood type as a risk factor in adverse pregnancy outcomes in Korea: a nationwide health insurance database study
Obstetrics & Gynecology Science
2020 .01
-
Ginsenoside-Rh2 Inhibits Proliferation and Induces Apoptosis of Human Gastric Cancer SGC-7901 Side Population Cells
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
General and Genetic Toxicology of Enzyme-Treated Ginseng Extract
Journal of Pharmacopuncture
2016 .01
최근 본 자료
댓글(0)
0