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논문 기본 정보

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학술저널
저자정보
박철호 (연세대학교) 한승규 (연세대학교) 김형우 (연세대학교 의과대학) 박정탁 (연세대학교) 한승혁 (연세대학교) 김승준 (가톨릭관동대학교) 강신욱 (연세대학교)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.43 No.1
발행연도
2024.1
수록면
93 - 100 (8page)
DOI
10.23876/j.krcp.23.162

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Background: Fluid overload is an independent risk factor of mortality in patients with acute kidney injury (AKI) receiving continuouskidney replacement therapy (CKRT). However, the association between fluid status, as assessed by bioelectrical impedance analysis(BIA) or lung ultrasound, and survival in patients with AKI requiring CKRT has not been established.Methods: We analyzed 36 participants with sepsis-associated AKI who received CKRT at a tertiary hospital. The main exposures werevolume surrogates: 1) overhydration normalized by extracellular water (OH/ECW, L/L) assessed by BIA, 2) the number of B-lines measuredby lung ultrasound, and 3) weight change ([body weight at CKRT initiation – body weight at admission] × 100/body weight atadmission). The primary outcome was the 28-day mortality.Results: Seventeen participants (47.2%) died within 28 days. There were no significant correlations between OH/ECW and weightchange (R2 = 0.040, p = 0.24), number of B-lines and OH/ECW (R2 = 0.056, p = 0.16), or weight change and number of B-lines (R2 =0.014, p = 0.49). Kaplan-Meier analyses revealed that patients in the highest tertile of OH/ECW showed a significantly lower cumulative28-day survival probability than the others (the lowest + middle tertiles). The survival probability of participants in the highest tertileof the number of B-lines or weight change did not differ from that of their counterparts. In a multivariate Cox proportional hazardmodel, the hazard ratio for the highest tertile of OH/ECW was 3.83 (95% confidence interval, 1.04–14.03).Conclusion: Volume overload assessed using BIA (OH/ECW) was associated with the 28-day survival rate in patients with sepsis-associatedAKI who received CKRT.

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