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논문 기본 정보

자료유형
학술저널
저자정보
Yusuke Kobayashi (Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan) Muneaki Shimada (Tohoku University School of Medicine, Sendai, Japan) Masato Tamate (Department of Obstetrics and Gynecology, Sapporo Medical University Hospital) Hyun-Woong Cho (Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of) Jun Zhu (Fudan University Shanghai Cancer Center/Shanghai Medical College, Fudan University) Hung-Hsueh Chou (Chang Gung University) Hiroaki Kajiyama (Nagoya University) Aikou Okamoto (The Jikei University School of Medicine) Daisuke Aoki (International University of Health and Welfare Graduate School, Tokyo, Japan) 강석범 (국림암센터) 이정원 (삼성서울병원) 김재원 (서울대학교) 김재훈 (연세대학교) Zhongqiu Lin (Sun Yat-sen Memorial Hospital) Ji-hong Liu (Department of Gynecology Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, China) Xiaohua Wu (Fudan University Shanghai Cancer Center) Hung-Cheng Lai (National Defense Medical Center, Taipei, Taiwan) Ting-Chang Chang (Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University) Chyong-Huey Lai (Chang Gung Memorial Hospital Linkou Branch) Yong-Man Kim (Asan Medical Center) Takayuki Enomoto (Niigata University School of Medicine, Niigata, Japan)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.35 No.3
발행연도
2024.5
수록면
1 - 19 (19page)
DOI
https://doi.org/10.3802/jgo.2024.35.e87

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초록· 키워드

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Ovarian cancer, notable for its severe prognosis among gynecologic cancers, has seensubstantial progress in treatment approaches recently. Enhanced protocols in chemotherapyand the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors for maintenancetherapy have markedly improved outcomes for patients with specific genetic profiles, suchas those positive for BRCA mutations or exhibiting homologous recombination deficiency(HRD). Additionally, the method of intraperitoneal chemotherapy administration has emerged as a valuable alternative to traditional transvenous routes, showing promise forwider clinical adoption. The field of surger y has also evolved, with increasing exploration intothe benefits and feasibility of laparoscopic methods over more invasive traditional surgeries,aiming for complete tumor removal but with reduced patient impact. The hereditar y natureof ovarian cancer underscores the importance of genetic testing, which has become integralin tailoring treatment strategies, particularly in determining suitability for PARP inhibitors. The formation of the East Asian Gynecologic Oncology Trial Group (EAGOT) aims tooptimize treatment across Japan, Korea, China, and Taiwan. The ovarian cancer committeeof EAGOT shared the current policies, focusing on 5 topics: 1) strategies for maintenancetherapy after initial surger y and chemotherapy, 2) drug regimens for platinum-sensitive andplatinum-resistant recurrence, 3) intraperitoneal chemotherapy, 4) laparoscopic surger y asan alternative to laparotomy, and 5) current status of genetic testing (BRCA, HRD, and paneltests) for ovarian cancer and its prospects. EAGOT’s multi-national trials aim to harmonizethese evolving treatment strategies, ensuring that the latest and most effective protocols areaccessible across the region, thereby significantly impacting patient outcomes in East Asia.

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