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논문 기본 정보

자료유형
학술저널
저자정보
Sergio Cortese (Hospital General Universitario Gregorio Marañón) Katherine Plua (Hospital Universitario Río Hortega) Alejandro J. Perez-Alonso (Hospital Virgen de las Nieves) María Savoie Hontoria (Hospital Universitario Nuestra Señora de Candelaria) David Pacheco (Hospital Universitario Río Hortega) Natalia Zambudio Carroll (Hospital Virgen de las Nieves) Manuel Ángel Barrera Gómez (Hospital Universitario Nuestra Señora de Candelaria) José María Pérez Peña (Hospital General Universitario Gregorio Marañón) Álvaro G. Morales Taboada (Hospital General Universitario Gregorio Marañón) María Fernández Martínez (Hospital General Universitario Gregorio Marañón) Sergio Hernández Kakauridze (Hospital General Universitario Gregorio Marañón) Ana María Matilla (Hospital General Universitario Gregorio Marañón) José Ángel López Baena (Hospital General Universitario Gregorio Marañón) José Manuel Asencio (Hospital General Universitario Gregorio Marañón)
저널정보
한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제28권 제4호
발행연도
2024.11
수록면
458 - 465 (8page)

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초록· 키워드

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Backgrounds/Aims: Thirty percent of liver grafts in donors after brain death (DBD) in Spain are rejected by procurement surgeons owing to marginal graft quality. Poor donor indocyanine green (ICG) clearance has been associated with graft discard and malfunction. This study aimed to internally and externally validate the predictive value of ICG-plasma disappearance rate (ICG-PDR) to reject grafts before donation and set a cut-off to avoid missing any potential effective donors.
Methods: Between March 2017 and August 2023, ICG clearance test was performed immediately before procurement in 71 DBD. The surgeon was blinded to test results. Univariate and multivariate analyses were performed to detect independent predictors of graft discard. Discrimination and calibration of predictors were assessed and a cut-off with 100% specificity was set. External validation was performed on 17 donors evaluated by three other transplantation teams.
Results: In the training cohort, 30 of 71 grafts were discarded for transplantation. ICG-PDR was the only donor variable independently associated with graft discard. The area under receiver operating characteristic curve for ICG-PDR was 0.875 (95% confidence interval: 0.768–0.947) and good calibration was observed. Below a PDR of 13.5%/min, no graft was accepted for transplantation. These results were successfully validated using the external cohort of donors.
Conclusions: ICG clearance test performed in DBD was internally and externally validated to predict liver graft discard. It could be used as a screening tool before donation to avoid unnecessary costs of travel and human resources.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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