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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.10 No.4
- 발행연도
- 2005.12
- 수록면
- 344 - 348 (5page)
이용수
초록· 키워드
오류제보하기
Fucoidans, high-molecular-weight sulfated polysaccharides extracted from brown seaweeds, have various biological activities. Here we examined whether fucoidan could increase the immunomodulation and proliferation capacity of cells in vitro. When peritoneal macrophages were treated with various concentrations of fucoidan (1~100 μg/mL) for 24 hours, NO production was significantly increased. In addition, exposure of macrophages to 10 μg/mL of fucoidan induced a phagocytic activity. Treatment of neuroblastoma cells (SK-N-SH) with fucoidan enhanced cell proliferation and NO production in a concentration-dependent manner. These results indicate that fucoidan has both immunomodulatory and cell proliferative properties, and may thus be a a candidate for development as an immunomodulating agent.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (24)
참고문헌 신청
Davis TA, Volesky B, Mucci A. 2003. A review of the biochemistry of heavy metal biosorption by brown algae. Water Res 37: 4311-4330.
Patel MK, Mulloy B, Gallagher KL, O'Brien L, Hughes AD. 2002. The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells. Thromb Haemost 87: 149-154.
O'Leary R, Rerek M, Wood EJ. 2004. Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in vitro models of dermal wound repair. Biol Pharm Bull 27: 266-270.
Mahony MC, Oehninger S, Clark GF, Acosta AA, Hodgen GD. 1991. Fucoidin inhibits the zona pellucida-induced acrosome reaction in human spermatozoa. Contraception 44: 657-665.
Baba M, Snoeck R, Pauwels R, de Clercq E. 1988. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antim
Patel MK, Mulloy B, Gallagher KL, O'Brien L, Hughes AD. 2002. The antimitogenic action of the sulphated polysaccharide fucoidan differs from heparin in human vascular smooth muscle cells. Thromb Haemost 87: 149-154.
O'Leary R, Rerek M, Wood EJ. 2004. Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in vitro models of dermal wound repair. Biol Pharm Bull 27: 266-270.
Mahony MC, Oehninger S, Clark GF, Acosta AA, Hodgen GD. 1991. Fucoidin inhibits the zona pellucida-induced acrosome reaction in human spermatozoa. Contraception 44: 657-665.
Baba M, Snoeck R, Pauwels R, de Clercq E. 1988. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antim
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UCI(KEPA) : I410-ECN-0101-2009-511-015199845