지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 307 - 313 (7page)
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초록· 키워드
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The development of in vitro assays has been recommended to screening and testing the potential endocrine disruptors (EDs). These assay systems focus only on identifying the estrogenic or antiestrogenic activity of EDs, whereas a few studies have been carried out to screen the thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detect TH disruptors using rat pituitary tumor GH₃ cells. The test system is based on the TH-dependent increase in growth rate. As expected, L-3,5,3-triiodothyronine (T₃) markedly induced a morphological change in GH₃ cells from flattened fibroblastic types to rounded or spindle-shaped types. T₃ stimulated GH₃ cell growth in a dose-dependent manner with the maximum growth-stimulating effect being observed at a concentration 1 × 10? M. In addition, T₃ increased the release of growth hormone and prolactin into the medium of the GH₃ cells culture. Using this assay system, the TH-disrupting activities of bisphenol A (BPA) and its related compounds were examined. BPA, dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH₃ cells in the range of 1 × 10??M to 1 × 10?? M concentrations. In conclusion, this in vitro assay system might be useful for identifying potential TH disruptors. However, this method will require further evaluation and standardization before it can be used as a broad-based screening tool.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENT
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-513-017647428