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논문 기본 정보

자료유형
학술저널
저자정보
Hyo-Jin An (Kyung Hee University) Hong-Kun Rim (Kyung Hee University) Jong-Hyun Lee (Kyung Hee University) Min-Jun Seo (Kyung Hee University) Jin-Woo Hong (Pusan National University) Na-Hyung Kim (Kyung Hee University) Noh-Yil Myung (Kyung Hee University) Phil-Dong Moon (Kyung Hee University) In-Young Choi (Wonkwang University) Ho-Jeong Na (Wonkwang University) Su-Jin Kim (Wonkwang University) Hyun-Ja Jeong (Hoseo University) Hyeung-Suk Park (WellLife R&D Center) Jae-Gab Han (WellLife R&D Center) Jae-Young Um (Kyung Hee University) Seung-Heon Hong (Wonkwang University) Hyung-Min Kim (Kyung Hee University)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 5
발행연도
2008.10
수록면
953 - 958 (6page)

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The object of this study was to investigate the immune-enhancing effects of Chlorella vulgaris (CV) on a deteriorated immune function by a protein-energy malnutrition (PEM) diet. Unicellular algae, CV were used as a biological response modifier. Male C57BL/6J mice were fed for 15 days with standard diet or a PEM diet, which is associated with decreased host immune defense. After 8 days, mice in the PEM diet group were orally administered by 0.05, 0.1, and 0.15 g/kg body weight of CV or distilled water. Nutritional parameters, and interferon (IFN)-γ levels were significantly increased in the blood serum of the CV (0.15 g/kg)-treated group (29.6±2.8 pg/mL) compared to the non-treated PEM group (4.1±0.4 pg/mL, p<0.05). In addition, cell proliferation and production of cytokines were investigated via a CV (0.01, 0.1, and 1 mg/mL) treatment using a human T cell line MOLT-4 cell. The CV treatment (1 mg/mL) significantly increased the production of both IFN-γ and interleukin (IL)-2 (51.3±3.4 and 285.9±18.8 pg/mL, respectively) compared to the control (51.3±3.4 and 442.6±14.3 pg/mL, respectively), but did not affect the production of IL-4. These results suggest that CV may be useful in improving the immune function.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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