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논문 기본 정보

자료유형
학술저널
저자정보
Jong Moon Hur (Sunchon National University) Jong Won Choi (Kyungsung University) Jong Cheol Park
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 16. no 3
발행연도
2007.6
수록면
439 - 443 (5page)

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The effects of the methanol extract of the leaves of Brassica juncea and isorhamnetin 3-o-β-D-glucopyranoside, major compound isolated from the ethyl acetate fraction of this plant on hepatic lipid peroxidation and drug-metabolizing enzymes, were evaluated in rats treated with bromobenzene. The extract and isorhamnetin 3-o-β-D-glucopyranoside of oral administration did not show any significant effects on activities of aminopyrine N-demethylase and aniline hydroxylase, enzymes forming toxic epoxide by bromobenzene as well as on glutathione content. However, both methanal extract and isorhamnetin 3-o-β-D-glucopyranoside significantly recovered the decreased activities of lutathione s-transferase and epoxide hydrolase, and also reduced the lipid peroxide level in rats treated with bromobenzene. From the results, the protections of this plant against bromobenzene-induced hepatotoxicity are thought to be via enhancing the activities of epoxide hydrolase and glutathione s-transferase, enzymes removing toxic epoxide, and reducing the lipid peroxide level.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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