지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.4
- 발행연도
- 2014.12
- 수록면
- 281 - 290 (10page)
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초록· 키워드
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The aim of the present study was to evaluate the anti-diabetic, anti-inflammatory, antioxidant potential, and total phenolic content (TPC) of green and red kohlrabi cultivars. Anti-diabetic and anti-inflammatory activities were evaluated via protein tyrosine phosphatase (PTP1B) and rat lens aldose reductase inhibitory assays and cell-based lipopolysaccharide (LPS)-induced nitric oxide (NO) inhibitory assays in RAW 264.7 murine macrophages. In addition, scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical, and peroxynitrite (ONOO?) were used to evaluate antioxidant potential and TPC was selected to assess phytochemical characteristics. Between the two kohlrabi cultivars, red kohlrabi (RK) had two times more TPC than green kohlrabi (GK) and showed significant antioxidant effects in DPPH, ABTS, and ONOO? scavenging assays. Likewise, methanol (MeOH) extracts of RK and GK inhibited LPS-induced NO production in a dose dependent manner that was further clarified by suppression of iNOS and COX-2 protein production. The MeOH extracts of RK and GK exhibited potent inhibitory activities against PTP1B with the corresponding IC50 values of 207±3.48 and 287±3.22 ㎍/mL, respectively. Interestingly, the RK MeOH extract exhibited significantly stronger anti-inflammatory, anti-diabetic, and antioxidant effects than that of GK MeOH extract. As a result, our study establishes that RK extract with a higher TPC might be useful as a potent anti-diabetic, antioxidant, and anti-inflammatory agent.
목차
ABSTRACT
INTRODUCTION
RESULTS
DISCUSSION
REFERENCES
참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Olokoba AB / 2012 / Type 2diabetes mellitus: a review of current trends / Oman Med J 27 : 269 ~ 273
2. [학술지(정기간행물)] - Khazrai YM / 2014 / Effect of diet on type 2 diabetes mellitus: a review / Diabetes Metab Res Rev 30 : 24 ~ 33
3. [학술지(정기간행물)] - Devasagayam TP / 2004 / Free radicals and antioxidants in human health: current status and future prospects / J Assoc Physicians India 52 : 794 ~ 804
4. [학술지(정기간행물)] - Singh PP / 2009 / Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2 / Indian J Clin Biochem 24 : 324 ~ 342
5. [학술지(정기간행물)] - Lee HS / 2002 / Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids / J Agric Food Chem 50 : 7013 ~ 7016
2. [학술지(정기간행물)] - Khazrai YM / 2014 / Effect of diet on type 2 diabetes mellitus: a review / Diabetes Metab Res Rev 30 : 24 ~ 33
3. [학술지(정기간행물)] - Devasagayam TP / 2004 / Free radicals and antioxidants in human health: current status and future prospects / J Assoc Physicians India 52 : 794 ~ 804
4. [학술지(정기간행물)] - Singh PP / 2009 / Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2 / Indian J Clin Biochem 24 : 324 ~ 342
5. [학술지(정기간행물)] - Lee HS / 2002 / Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids / J Agric Food Chem 50 : 7013 ~ 7016
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