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자료유형
학술저널
저자정보
저널정보
대한지역사회영양학회 Journal of Community Nutrition Journal of Community Nutrition Vol.4 No.3
발행연도
2002.11
수록면
187 - 194 (8page)

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This study was investigated the effects of exercise and supplementation of L-carnitine and antioxidants on hepatic mitochondrial function, especially oxidative phosphorylation (OXPHOS). Isolated hepatic mitochondria from 4 rat groups were functionally tested by an analysis of respiration and the coupling of this process to ATP systhesis in the presence of ADP. Four groups were non-trained, non-supplemented group(NTNS), non-trained, supplemented group(NTS), long tern-trained, non-supplemented group(LTNS), and long term-trained, supplemented group(LTS). The trained rats run on a treadmill(grade 10˚ . 20m/min( for 60min/day for 8 weeks. The supplemented rats were treated with L-carnitine(0.5% diet), vitamin E(0.5mg/g BW), vitamin C(0.5mg/g BW) and melatonin(1μg/g BW) for 8 weeks. tThere were exercise effects on improving mitochondrial OXPHOS. Within non-supplemented groups, exercised rats resulted in a significant decrease in state 4 oxygen consumption, which increased the respiratory control(RC) ratio and ADP : O(P/O) ratio. There were supplementation effects on improving mitochondrial OXPHOS, too. Within non-exercised rats, supplemented rats resulted in a significant decrease in state 4 oxygen consuption, which increase the RC ratio and P/O ratio. There were additive effects of exercise and supplementation on OXPHOS. Within supplemented rats, exercise resulted in an increase in RC ratio. Significant effexts of exercise-supplement interaction on improving OXPHOS were identified. It suggests that exercise and supplementation of L-carnitine and antioxidants might improve more effeciently the impared OXPHOS efficiency in mitochondrial dysfunction that recognized as is an importane cause of degenerative diseases. (J Community Nutrition 4(3) : 187~194, 2002)

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