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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.1
- 발행연도
- 2016.3
- 수록면
- 38 - 43 (6page)
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초록· 키워드
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Matrix metalloproteinases (MMPs) are crucial extracellular matrices degrading enzymes that take important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. Natural products are on the rise for their potential to provide remarkable health benefits. In this context, halophytes have been of interest in the nutraceutical field with reported instances of isolation of bioactive compounds. In this study, Limonium tetragonum, an edible halophyte, was studied for its ability to inhibit MMP-2 and -9 using HT1080 fibrosarcoma cells. Results showed that L. tetragonum extract was able to inhibit the enzymatic activity and mRNA expression of MMP-2 and -9 according to gelatin zymography and RT-PCR assays, respectively, but it was not able to significantly change the MMP pathway related factors such as tissue inhibitors of metalloproteinases. Also, Mitogen-activated protein kinases pathway-related protein levels and their phosphorylation were assayed. While the phosphorylated p38 levels were decreased, extracellular signal-regulated kinase and c-Jun N-terminal kinase were not affected by L. tetragonum treatment. In conclusion, it was suggested that L. tetragonum contains substances acting as MMP inhibitors on enzymatic activity rather than intracellular pathway intervention, which could be useful for further utilization of L. tetragonum as a source for anti-MMP agents.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
da Rocha AB, Lopes RM, Schwartsmann G. 2001. Natural products in anticancer therapy. Curr Opin Pharmacol 1: 364- 369.
Kim YA, Kong CS, Lee JI, Kim H, Park HY, Lee HS, Lee C, Seo Y. 2012. Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea. Bioorg Med Chem Lett 22: 4318-4322.
Ksouri R, Smaoui A, Isoda H, Abdelly C. 2012. Utilization of halophyte species as new sources of bioactive substances. J Arid Land Stud 22: 41-44.
Lee JI, Kong CS, Jung ME, Hong JW, Noh I, Seo Y. 2011. Peroxynitrite- scavenging activity of the halophyte Limonium tetragonum. Ocean Polar Res 33: 185-191.
Yang MH, Kim NH, Heo JD, Sung SH, Jeong EJ. 2014. Hepatoprotective effects of Limonium tetragonum, edible medicinal halophyte growing near seashores. Pharmacogn Mag 10: 563- 568.
Kim YA, Kong CS, Lee JI, Kim H, Park HY, Lee HS, Lee C, Seo Y. 2012. Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea. Bioorg Med Chem Lett 22: 4318-4322.
Ksouri R, Smaoui A, Isoda H, Abdelly C. 2012. Utilization of halophyte species as new sources of bioactive substances. J Arid Land Stud 22: 41-44.
Lee JI, Kong CS, Jung ME, Hong JW, Noh I, Seo Y. 2011. Peroxynitrite- scavenging activity of the halophyte Limonium tetragonum. Ocean Polar Res 33: 185-191.
Yang MH, Kim NH, Heo JD, Sung SH, Jeong EJ. 2014. Hepatoprotective effects of Limonium tetragonum, edible medicinal halophyte growing near seashores. Pharmacogn Mag 10: 563- 568.
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UCI(KEPA) : I410-ECN-0101-2016-594-002777599