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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.3
- 발행연도
- 2017.9
- 수록면
- 184 - 190 (7page)
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초록· 키워드
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Matrix metalloproteinases (MMPs) are endopeptidases that take significant roles in extracellular matrix degradation and therefore linked to several complications such as metastasis of cancer progression, oxidative stress, and hepatic fibrosis. Hizikia fusiformis, a brown algae, was reported to possess bioactivities, including but not limited to, antiviral, antimicrobial, and anti-inflammatory partly due to bioactive polysaccharide contents. In this study, the potential of H. fusiformis against cancer cell invasion was evaluated through the MMP inhibitory effect in HT1080 fibrosarcoma cells in vitro. H. fusiformis crude extract was fractionated with organic solvents, H₂O, n-BuOH, 85% aqueous MeOH, and n-hexane (n-Hex). The non-toxicity of the fractions was confirmed by MTT assay. All fractions inhibited the enzymatic activities of MMP-2 and MMP-9 according to the gelatin zymography assay. Cell migration was also significantly inhibited by the n-Hex fraction. In addition, both gene and protein expressions of MMP-2 and -9, and tissue inhibitor of MMPs (TIMPs) were evaluated by reverse transcription-polymerase chain reaction and Western blotting, respectively. The fractions suppressed the mRNA and protein levels of MMP-2, MMP-9 while elevating the TIMP-1 and TIMP-2, with the H₂O fraction being the least effective while n-Hex fraction the most. Collectively, the n-Hex fraction from brown algae H. fusiformis could be a potential inhibitor of MMPs, suggesting the presence of various derivatives of polysaccharides in high amounts.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
[학술지(정기간행물)] - Deryugina EI / 2015 / Tumor angiogenesis: MMPmediated induction of intravasation- and metastasis-sustaining neovasculature / Matrix Biol 44-46 : 94 ~ 112
[학술지(정기간행물)] - Shuman Moss LA / 2012 / Matrix metalloproteinases : changing roles in tumor progression and metastasis / Am J Pathol 181 : 1895 ~ 1899
[학술지(정기간행물)] - Shay G / 2015 / Moving targets: emerging roles for MMPs in cancer progression and metastasis / Matrix Biol 44-46 : 200 ~ 206
[학술지(정기간행물)] - Gialeli C / 2011 / Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting / FEBS J 278 : 16 ~ 27
[학술지(정기간행물)] - Thomas NV / 2010 / Metalloproteinase inhibitors : status and scope from marine organisms / Biochem Res Int 2010 : 845975 ~
[학술지(정기간행물)] - Shuman Moss LA / 2012 / Matrix metalloproteinases : changing roles in tumor progression and metastasis / Am J Pathol 181 : 1895 ~ 1899
[학술지(정기간행물)] - Shay G / 2015 / Moving targets: emerging roles for MMPs in cancer progression and metastasis / Matrix Biol 44-46 : 200 ~ 206
[학술지(정기간행물)] - Gialeli C / 2011 / Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting / FEBS J 278 : 16 ~ 27
[학술지(정기간행물)] - Thomas NV / 2010 / Metalloproteinase inhibitors : status and scope from marine organisms / Biochem Res Int 2010 : 845975 ~
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UVB에 조사된 HaCaT Keratinocytes에서의 유색미에 의한 Matrix Metalloproteinases 발현억제 메커니즘
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MMP Inhibitory Effect of Solvent Extracts from Limonium tetragonum in PMA-stimulated Human Fibrosarcoma Cells
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Ecklonia cava-Hizikia fusiformis complex extract alleviates inflammation in human lung epithelia
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UCI(KEPA) : I410-ECN-0101-2018-594-001354794