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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 140 - 145 (6page)
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초록· 키워드
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Ophiocordyceps sinensis is a natural fungus that has been valued as a health food and used in traditional Chinese medicine for centuries. The fungus is parasitic and colonizes insect larva. Naturally occurring O. sinensis thrives at high altitude in cold and grassy alpine meadows on the Himalayan mountain ranges. Wild Ophiocordyceps is becoming increasingly rare in its natural habitat, and its price limits its use in clinical practice. Therefore, the development of a standardized alternative is a great focus of research to allow the use of Ophiocordyceps as a medicine. To develop an alternative for wild Ophiocordyceps, a refined standardized extract, CBG-CS-2, was produced by artificial fermentation and extraction of the mycelial strain Paecilomyces hepiali CBG-CS-1, which originated from wild O. sinensis. In this study, we analyzed the in vitro immune-modulating effect of CBG-CS-2 on natural killer cells and B and T lymphocytes. CBG-CS-2 stimulated splenocyte proliferation and enhanced Th1-type cytokine expression in the mouse splenocytes. Importantly, in vitro CBG-CS-2 treatment enhanced the killing activity of the NK-92MI natural killer cell line. These results indicate that the mycelial culture extract prepared from Ophiocordyceps exhibits immune-modulating activity, as was observed in vivo and this suggests its possible use in the treatment of diseases caused by abnormal immune function.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Sung, J. M., H. K. Lee, Y. S. Choi, Y. Y. Kim, S. H. Kim, and G. H. Sung. 1997. Distribution and taxonomy of entomopathogenic fungal species from Korea. Kor. J. Mycol. 25: 239-252.
Sung, J. M., C. H. Kim, K. J. Yang, H. K. Lee, and Y. S. Kim. 1993. Studies on distribution and utilization of Cordyceps militaris and C. nutans. Kor. J. Mycol. 21: 94-105.
Sung, J. M., H. K. Lee, Y. J. Yoo, Y. S. Choi, S. H. Kim, Y. O. Kim, and S. H. Sung. 1998. Classification of Cordyceps species based on protein banding pattern. Kor. J. Mycol. 26: 1-7.
Sung, G. H., N. L. Hywel-Jones, J. M. Sung, J. J. Luangsa-ard, B. Shrestha, and J. W. Spatafora. 2007. Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Stud. Mycol. 57: 5-59.
Jang, Y. S., and S. W. Hong. 1986. Notes on unrecorded fresh fungi of Cordyceps in Korea. Kor. J. Mycol. 14: 85-88.
Sung, J. M., C. H. Kim, K. J. Yang, H. K. Lee, and Y. S. Kim. 1993. Studies on distribution and utilization of Cordyceps militaris and C. nutans. Kor. J. Mycol. 21: 94-105.
Sung, J. M., H. K. Lee, Y. J. Yoo, Y. S. Choi, S. H. Kim, Y. O. Kim, and S. H. Sung. 1998. Classification of Cordyceps species based on protein banding pattern. Kor. J. Mycol. 26: 1-7.
Sung, G. H., N. L. Hywel-Jones, J. M. Sung, J. J. Luangsa-ard, B. Shrestha, and J. W. Spatafora. 2007. Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Stud. Mycol. 57: 5-59.
Jang, Y. S., and S. W. Hong. 1986. Notes on unrecorded fresh fungi of Cordyceps in Korea. Kor. J. Mycol. 14: 85-88.
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UCI(KEPA) : I410-ECN-0101-2016-511-002817851