지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 233 - 241 (9page)
이용수
초록· 키워드
오류제보하기
DCs, like the sensory neurons, express vanilloid receptor 1 (VR1). Here we demonstrate that the VR1 agonists, capsaicin (CP) and resiniferatoxin (RTX), enhance antiviral CTL responses by increasing MHC class I-restricted viral antigen presentation in dendritic cells (DCs). Bone marrow-derived DCs (BM-DCs) were infected with a recombinant vaccinia virus (VV) expressing OVA (VV-OVA), and then treated with CP or RTX. Both CP and RTX increased MHC class I-restricted presentation of virus-encoded endogenous OVA in BM-DCs. Oral administration of CP or RTX significantly increased MHC class I-restricted OVA presentation by splenic and lymph node DCs in VV-OVA-infected mice, as assessed by directly measuring OVA peptide SIINFEKL-K<SUP>b</SUP> complexes on the cell surface and by performing functional assays using OVA-specific CD8 T cells. Accordingly, oral administration of CP or RTX elicited potent OVA-specific CTL activity in VV-OVA-infected mice. The results from this study demonstrate that VR1 agonists enhance anti-viral CTL responses, as well as a neuro-immune connection in anti-viral immune responses.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
[학술지(정기간행물)] - Caterina, M. J / 1997 / The capsaicin receptor: a heat-activated ion channel in the pain pathway / Nature 389 : 816 ~ 824
[학술지(정기간행물)] - Szallasi, A / 1999 / Vanilloid (Capsaicin)receptors and mechanisms / Pharmacol. Rev 51 : 159 ~ 212
[학술지(정기간행물)] - Szallasi, A / 2007 / The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept / Nat. Rev. Drug Discov 6 : 357 ~ 372
[학술지(정기간행물)] - Everaerts, W / 2011 / The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil / Curr. Biol 21 : 316 ~ 321
[학술지(정기간행물)] - Holzer, P / 1991 / Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons / Pharmacol. Rev 43 : 143 ~ 201
[학술지(정기간행물)] - Szallasi, A / 1999 / Vanilloid (Capsaicin)receptors and mechanisms / Pharmacol. Rev 51 : 159 ~ 212
[학술지(정기간행물)] - Szallasi, A / 2007 / The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept / Nat. Rev. Drug Discov 6 : 357 ~ 372
[학술지(정기간행물)] - Everaerts, W / 2011 / The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil / Curr. Biol 21 : 316 ~ 321
[학술지(정기간행물)] - Holzer, P / 1991 / Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons / Pharmacol. Rev 43 : 143 ~ 201
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UCI(KEPA) : I410-ECN-0101-2017-517-000981476