Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats

Ali Reza Fallahzadeh; Zohreh Rezaei; Hamid Reza Rahimi; Mehrazd Jafari Barmak; Hossein Sadeghi; Sadrollah Mehrabi; Seyed Mohammadreza Rabani; Iraj Ragerdi Kashani; Vahid Barati; Reza Mahmoudi

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저자정보: Ali Reza Fallahzadeh (Yasuj University of Medical Sciences) Zohreh Rezaei (Yasuj University of Medical Sciences) Hamid Reza Rahimi (Kerman University of Medical Sciences) Mehrazd Jafari Barmak (Yasuj University of Medical Sciences) Hossein Sadeghi (Yasuj University of Medical Sciences) Sadrollah Mehrabi (Yasuj University of Medical Sciences) Seyed Mohammadreza Rabani (Yasuj University of Medical Sciences) Iraj Ragerdi Kashani (Tehran University of Medical Sciences) Vahid Barati (Yasuj University of Medical Sciences) Reza Mahmoudi (Yasuj University of Medical Sciences)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.33 No.3

발행연도: 2017.6

수록면: 255 - 263 (9page)

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Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat a number of cancers has been reported to most likely induce testicular toxicity. Administration of antioxidants, such as pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) of CDDP. Therefore, this study investigated the potentially protective effects of PTX on CDDP-induced testicular toxicity in adult male rats. For this purpose, 42 male rats were randomly divided into 7 groups. The rats were orally pretreated with PTX at the 3 doses of 75, 150, and 300 mg/kg once a day for 14 successive days. On the 14<SUP>th</SUP> day of the study, they were intraperitoneally (IP) administered with a single dose of CDDP (7 mg/kg). Finally, the sperm/testis parameters, serum levels of reproductive hormones, including testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) as the pivotal endocrine factors controlling testicular functions, and histopathological changes of testis tissue were examined. Pretreatment with the two doses of 75 and 150 mg/kg PTX indicated significant increases in the sperm count and motility induced by CDDP administration. The right and significantly left testis weights were decreased following the treatment with 300 mg/kg of PTX plus CDDP. However, 75 mg/kg of PTX plus CDDP showed the best near-to-normal histopathological features. The results demonstrated that PTX alone enhanced some parameters, such as the sperm count, while reducing other parameters, including sperm fast motility and germ layer thickness. Furthermore, despite testosterone or LH levels, the mean serum FSH level was significantly augmented by the doses of 75 and 150 mg/kg. It was concluded that PTX administration cannot reduce CDDP-induced testicular toxicity even at high doses (e.g., 300 mg/kg), while it seemed to partially intensify CDDP toxicity effects at a dose of 75 mg/kg. Thus, further research is required in this regard.

#Chemotherapy #Testicular toxicity #Antioxidant #Histopathological feature #Sperm motility

참고문헌 (50)

참고문헌 신청

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