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논문 기본 정보

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학술저널
저자정보
Kang, Hee Jung (Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Lee, Sun-Hee (Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Park, Yong-Seog (Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Lim, Chun Kyu (Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Ko, Duck Sung (Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Yang, Kwang Moon (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Park, Dong-Wook (Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Dankook University Coll)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제42권 제2호
발행연도
2015.1
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45 - 50 (6page)

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Objective: Artificial oocyte activation (AOA) is an effective method to avoid total fertilization failure in human in vitro fertilization-embryo transfer (IVF-ET) cycles. AOA performed using a calcium ionophore can induce calcium oscillation in oocytes and initiate the fertilization process. We evaluated the usefulness of AOA with a calcium ionophore in cases of total fertilization failure in previous cycles and in cases of severe male factor infertility patients with non-motile spermatozoa after pentoxifylline (PF) treatment. Methods: The present study describes 29 intracytoplasmic sperm injection (ICSI)-AOA cycles involving male factor infertility at Cheil General Hospital from January 2006 to June 2013. Patients were divided into two groups (control, n=480; AOA, n=29) depending on whether or not AOA using a calcium ionophore (A23187) was performed after testicular sperm extraction-ICSI (TESE-ICSI). The AOA group was further split into subgroups according to sperm motility after PF treatment: i.e., motile sperm-injected (n=12) and non-motile sperm-injected (n=17) groups (total n=29 cycles). Results: The good embryo rate (52.3% vs. 66.9%), pregnancy rate (20.7% vs. 52.1%), and delivery rate (10.3% vs. 40.8%) were lower in the PF/AOA group than in the control group. When evaluating the effects of restoration of sperm motility after PF treatment on clinical outcomes there was no difference in fertilization rate (66.6% vs. 64.7% in non-motile and motile sperm, respectively), pregnancy rate (17.6% vs. 33.3%), or delivery rate (5.9% vs. 16.7%) between the two groups. Conclusion: We suggest that oocyte activation is a useful method to ensure fertilization in TESE-ICSI cycles regardless of restoration of sperm motility after PF treatment. AOA may be useful in selected patients who have a low fertilization rate or total fertilization failure.
#Artificial oocyte activation #Calcium ionophore #Intracytoplasmic sperm injection #Pentoxifylline #Testicular sperm extraction

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