ICSI significantly improved the pregnancy rate of patients with a high sperm DNA fragmentation index

Chi, Hee-Jun; Kim, Seok-Gi; Kim, Youn-Young; Park, Ji-Young; Yoo, Chang-Seok; Park, Il-Hae; Sun, Hong-Gil; Kim, Jae-Won; Lee, Kyeong-Ho; Park, Hum-Dai

추천

검색

자료유형: 학술저널

저자정보: Chi, Hee-Jun (IVF Center, Mamapapa and Baby Clinic) Kim, Seok-Gi (IVF Center, Mamapapa and Baby Clinic) Kim, Youn-Young (IVF Center, Mamapapa and Baby Clinic) Park, Ji-Young (IVF Center, Mamapapa and Baby Clinic) Yoo, Chang-Seok (IVF Center, Mamapapa and Baby Clinic) Park, Il-Hae (IVF Center, Mamapapa and Baby Clinic) Sun, Hong-Gil (IVF Center, Mamapapa and Baby Clinic) Kim, Jae-Won (IVF Center, Mamapapa and Baby Clinic) Lee, Kyeong-Ho (IVF Center, Mamapapa and Baby Clinic) Park, Hum-Dai (Department of Biotechnology, Daegu University)

저널정보: 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제44권 제3호

발행연도: 2017.1

수록면: 132 - 140 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective: Correlations between semen parameters and sperm DNA fragmentation index (DFI) were investigated to identify characteristics of sperm without DNA damage that could be used in selecting sperm for intracytoplasmic sperm injection (ICSI). Pregnancy outcomes were compared to determine whether in vitro fertilization (IVF) or ICSI is a better choice for patients who have sperm with a high-DFI. Methods: Semen analysis was carried out in 388 patients who visited our IVF center for the first time to investigate correlations between sperm DFI and semen parameters. In addition, 1,102 IVF cycles in 867 patients were carried out in the present study; 921 cycles in the low-DFI group (DFI < 30%) and 181 cycles in the high-DFI group ($DFI{\geq}30%$). Both the low- and high-DFI groups were subdivided into IVF and ICSI cycle groups. Results: Sperm DFI showed significant inverse correlations with sperm motility (r = -0.435, p< 0.001) and morphology (r = -0.153, p< 0.05). Sperm DFI also showed significant correlations with rapid motility (r = -0.436, p< 0.001), and the kinetic parameters of average-path velocity (r = -0.403) and linearity (r = -0.412). Although there was no significant difference in the pregnancy rates between IVF (48.6%) and ICSI (44.8%) in the low-DFI group, the pregnancy rate of ICSI cycles (44.8%, p< 0.05) was significantly higher than IVF cycles (25.0%) in the high-DFI group. No significant difference was observed in the abortion rates between the low-DFI (52 of 921, 5.6%) and high-DFI groups (7 of 181, 3.8%). Conclusion: ICSI is a better choice than IVF for improving the pregnancy outcomes of patients who have sperm with a high DFI.

#Sperm DNA fragmentation index #Sperm injections, intracytoplasmic #Sperm morphology #Sperm motility

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!