Highly Active Antiretroviral Therapy Alters Sperm Parameters and Testicular Antioxidant Status in Diet-Induced Obese Rats

Ibukun P. Oyeyipo; Bongekile T. Skosana; Frans P. Everson; Hans Strijdom; Stefan S. du Plessis

추천

검색

질문

자료유형: 학술저널

저자정보: Ibukun P. Oyeyipo (Stellenbosch University) Bongekile T. Skosana (Stellenbosch University) Frans P. Everson (Stellenbosch University) Hans Strijdom (Stellenbosch University) Stefan S. du Plessis (Stellenbosch University)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.34 No.1

발행연도: 2018.1

수록면: 41 - 48 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180~200 g) were assigned randomly into 4 groups and treated accordingly for 16 weeks as follows: Control (C): lean group fed with standard rat chow; Diet induced obesity (DIO): obese animals fed a high caloric diet; C + ART: lean animals treated with HAART; DIO + ART: obese animals treated with HAART. An antiretroviral drug combination of Tenofovir, Emtricitabine and Efavirenz at a dose of 17, 26 and 50 mg/kg/day was administered for the latter 6 weeks via jelly cube feeding. At the end of the experimental period, sperm analysis was performed on sperm collected from the caudal epididymis, while the testis was homogenized for antioxidant enzyme and lipid peroxidation assays. Results showed that HAART significantly decreased sperm motility (p < 0.05) in both lean and obese animals, and viability (p < 0.05) in the DIO group. Testicular glutathione, catalase and superoxide dismutase were significantly decreased (p < 0.05), while Thiobarbituric acid reactive substances (TBARS) levels were significantly increased (p < 0.05) when the DIO+ART group was compared to Control group. Thus, the decreased sperm qualities associated with HAART might be as a result of increased testicular oxidative stress prominent in obese animals.

#Highly active antiretroviral therapy #Obesity #Sperm #Motility #Velocity #Testicular antioxidants

참고문헌 (41)

참고문헌 신청

Pozniak, A.L. / 2006 / Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes--a 96-week analysis / J. Acquir. Immune Defic. Syndr. 43:535~540

Palella, F.J. Jr. / 1998 / Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators / N. Engl. J. Med. 338:853~860

Bujan, L. / 2007 / Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment / J. Androl. 28:444~452

Kayode, A.A. / 2011 / Hematologic and hepatic enzyme alterations associated with acute administration of antiretroviral drugs / J. Pharmacol. Toxicol. 6:293~302

Kushnir, V.A. / 2011 / Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active anti- retrovirals / Fertil Steril. 96:546~553

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!