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논문 기본 정보

자료유형
학술저널
저자정보
Jae-Kyoo Lee (Seoul Government Research Institute of Public Health and Environment) Ouk-Hee Kim (Seoul Government Research Institute of Public Health and Environment) Bo-Kyung Jung (Seoul Government Research Institute of Public Health and Environment) In-Soon Cho (Seoul Government Research Institute of Public Health and Environment) Yun-Jung Lee (Seoul Government Research Institute of Public Health and Environment) Hee-Jin Choi (Seoul Government Research Institute of Public Health and Environment) Youn-Cheon Kim (Seoul Government Research Institute of Public Health and Environment) Young-Hee Oh (Seoul Government Research Institute of Public Health and Environment) Kweon Jung (Seoul Government Research Institute of Public Health and Environment) Seung-Hyeon Cha (Chungbuk National University) Keum-Il Jang (Chungbuk National University)
저널정보
한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.1
발행연도
2019.3
수록면
75 - 83 (9page)
DOI
10.3746/pnf.2019.24.1.75

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Flavonoids are a major component of Ginkgo biloba extract (GBE). Several studies have investigated chelate formation and the redox reaction between flavonoids and metal ions; however, the effect of mineral supplements on the results from the analysis of the flavonol glycoside content in products containing GBE dietary supplement remains unknown. In this study, the effects of commonly used mineral supplements on the recovery of quercetin from GBE-containing dietary supplements were investigated using conventional methods of flavonol glycoside determination. Mineral supplements containing Zn (II), Mn (II), and Fe (II) did not affect quercetin recovery, whereas Cu (II) and Fe (III) significantly reduced recovery (P<0.05). Quercetin oxidation was prevented by adding an antioxidant to the diluent (extraction solvent). Among the tested synthetic antioxidants, tert-butyl hydroquinone (TBHQ) promoted the greatest increase in quercetin recovery. The flavonol glycoside content of commercially available GBE-containing dietary supplements was analyzed using a conventional diluent or a diluent containing 20 mg/mL TBHQ. The amount of quercetin recovered from products containing Cu (II) was found to decrease with increasing hydrolysis duration and the duration in the final test solution state using the conventional diluent, while the TBHQ-containing diluent yielded consistent quercetin contents (P<0.05). These findings suggest that quercetin, a major aglycone of GBE flavonol glycosides, can be oxidized by Cu (II) and Fe (III) during the analytical process and, therefore, the total flavonol glycoside content may be underestimated. The addition of TBHQ to the diluent can improve the accuracy and reproducibility of flavonol glycoside content analysis in GBE-containing dietary products supplemented with minerals.
#Ginkgo biloba #flavonol glycoside #quercetin #oxidation #TBHQ

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES

참고문헌 (30)

참고문헌 신청
Zhao Y / 2010 / Out of China : distribution history of Ginkgo biloba L / Taxon 59:495~504 google schola Singh B / 2008 / Biology and chemistry of Ginkgo biloba / Fitoterapia 79:401~418 google schola IARC Monographs Working Group / 2013 / Some drugs and herbal products: IARC monographs on the evaluation of carcinogenic risks to humans Vol 108 / WHO Press :91~116 google schola Rai GS / 1991 / A double-blind, placebo controlled study of Ginkgo biloba extract(‘tanakan’)in elderly outpatients with mild to moderate memory impairment / Curr Med Res Opin 12:350~355 google schola Mouren X / 1994 / Study of the antiischemic action of EGb 761 in the treatment of peripheral arterial occlusive disease by TcPo2 determination / Angiology 45:413~417 google schola

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UCI(KEPA) : I410-ECN-0101-2019-594-000543231