지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 242 - 251 (10page)
이용수
초록· 키워드
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Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy.
Methods: This study was conducted to evaluate the potential toxicological effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to SpragueeDawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven SpragueeDawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on maternal function and embryo-fetal development.
Results and conclusion: No test itemerelated changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have toxicological potential on developmental and reproductive functions. Therefore, no observed adverse effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.
Methods: This study was conducted to evaluate the potential toxicological effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to SpragueeDawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven SpragueeDawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on maternal function and embryo-fetal development.
Results and conclusion: No test itemerelated changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have toxicological potential on developmental and reproductive functions. Therefore, no observed adverse effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion and conclusion
References
참고문헌 (38)
참고문헌 신청
Jeon BH / 2000 / Effect of Korean red ginseng on blood pressure and nitric oxide production / Acta Pharmacol Sinica 21:1095~1100
Jae Gwang Park / 2016 / Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells / Journal of Ginseng Research 40(4):431~436
김현정 / 2010 / Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats / Journal of Ginseng Research 34(2):104~112
Lee YK / 2013 / Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metfomin in rats / Food Chem Toxicol 59:153~159
Qureshi AA / 1983 / Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver / Atherosclerosis 48(1):81~94
Jae Gwang Park / 2016 / Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells / Journal of Ginseng Research 40(4):431~436
김현정 / 2010 / Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats / Journal of Ginseng Research 34(2):104~112
Lee YK / 2013 / Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metfomin in rats / Food Chem Toxicol 59:153~159
Qureshi AA / 1983 / Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver / Atherosclerosis 48(1):81~94
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