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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 808 - 817 (10page)
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Background/Aims: Peginterferon plus ribavirin remains a standard therapy for patients with chronic hepatitis C (CHC) in Korea. We investigated the efficacy and long-term outcome of peginterferon and ribavirin therapy in Korean patients with CHC, particularly in relation to the stage of liver fibrosis. Methods: The incidence of sustained virological response (SVR), hepatic decompensation, hepatocellular carcinoma, and liver-related death was analyzed in 304 patients with CHC; the patients were followed up for a median of 54 months. Results: Among patients with HCV genotype 1, the SVR rate was 36.7% (18/49) and 67% (69/103) for patients with and without cirrhosis, respectively (p<0.001). For patients with non-1 HCV genotypes, the SVR rates were 86.0% (37/43) in cirrhotic patients and 86.2% (94/109) in noncirrhotic patients. SVR significantly reduced the risk of liverrelated death, hepatic decompensation, and hepatocellular carcinoma, which had hazard ratios of 0.27, 0.16, and 0.22, respectively (all p<0.05). However, despite the SVR rate, patients with advanced fibrosis were still at risk of developing liver-related complications. Conclusions: A relatively high SVR rate was achieved by peginterferon plus ribavirin therapy in Korean patients with CHC, which improved their long-term outcomes. However, all CHC patients with advanced hepatic fibrosis should receive close follow-up observations, even after successful antiviral treatment.
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참고문헌 (28)
참고문헌 신청
Mohd Hanafiah K / 2013 / Global epidemiology of hepatitis C virus infection: new estimates of agespecific antibody to HCV seroprevalence / Hepatology 57:1333~1342
Shin HR / 2006 / Epidemiology of hepatitis C virus in Korea / Intervirology 49:18~22
Maasoumy B / 2012 / Natural history of acute and chronic hepatitis C / Best Pract Res Clin Gastroenterol 26:401~412
Perz JF / 2006 / The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide / J Hepatol 45:529~538
Bruno S / 2007 / Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study / Hepatology 45:579~587
Shin HR / 2006 / Epidemiology of hepatitis C virus in Korea / Intervirology 49:18~22
Maasoumy B / 2012 / Natural history of acute and chronic hepatitis C / Best Pract Res Clin Gastroenterol 26:401~412
Perz JF / 2006 / The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide / J Hepatol 45:529~538
Bruno S / 2007 / Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study / Hepatology 45:579~587
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