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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 456 - 463 (8page)
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Background/Aims: The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients. Methods: We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014.
Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software. Results: The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG: OR, 2.29; 95% CI, 1.57 to 3.35; p<0.05) but not Asian populations. In Caucasians, liver steatosis was also more severe in CHC patients with rs738409 GG (versus CC+CG; OR, 4.33; 95% CI, 2.59 to 7.22; p<0.05). The sensitivity analysis indicated the results of this meta-analysis were stable and no publication bias was detected. Conclusions: PNPLA3 rs738409 (C>G) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations.
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참고문헌 (34)
참고문헌 신청
Shepard CW / 2005 / Global epidemiology of hepatitis C virus infection / Lancet Infect Dis 5:558~567
Seeff LB / 2009 / The history of the"natural history"of hepatitis C(1968-2009) / Liver Int 29(1):89~99
Niederau C / 1998 / Prognosis of chronic hepatitis C: results of a large, prospective cohort study / Hepatology 28:1687~1695
Bochud PY / 2009 / Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C / J Hepatol 51:655~666
Davis GL / 2010 / Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression / Gastroenterology 138(e6):513~521
Seeff LB / 2009 / The history of the"natural history"of hepatitis C(1968-2009) / Liver Int 29(1):89~99
Niederau C / 1998 / Prognosis of chronic hepatitis C: results of a large, prospective cohort study / Hepatology 28:1687~1695
Bochud PY / 2009 / Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C / J Hepatol 51:655~666
Davis GL / 2010 / Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression / Gastroenterology 138(e6):513~521
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